We present RegulomePA, a database that contains biological information on regulatory interactions between transcription factors (TFs), sigma factor (SFs) and target genes in Pseudomonas aeruginosa PAO1. RegulomePA consists of 4827 regulatory interactions between 2831 nodes, which represent the interactions of TFs and SFs with their target genes, from the total of predicted RegulomePA including 27.27% of the TFs, 54.16% of SFs and 50.8% of the total genes. Each entry in the database corresponds to one node in the network and provides comprehensive details about the gene and its regulatory interactions such as gene description, nucleotide sequence, genome-strand position and links to other databases as well as the type of regulation it exerts or to which it is being subject (repression or activation), the associated experimental evidence and references, and topological information. Additionally, RegulomePA provides a way to recover information on the regulatory circuits of the network to which a gene pertains and also makes available the source codes to analyze the topology of any other regulatory network. The database will be updated yearly, by our team, with the contributions from ourselves and users, since the users are provided with an interactive platform where they can add interactions to the regulatory network feeding it with their respective references.

中文翻译：

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RegulomePA：铜绿假单胞菌 PAO1 转录调控相互作用数据库

我们推出了 RegulomePA，这是一个数据库，其中包含铜绿假单胞菌PAO1中转录因子 (TF)、西格玛因子 (SF) 和靶基因之间调控相互作用的生物学信息。RegulomePA由2831个节点之间的4827个调控相互作用组成，代表TF和SF与其目标基因的相互作用，预测的RegulomePA总数包括27.27%的TF、54.16%的SF和总基因的50.8%。数据库中的每个条目对应于网络中的一个节点，并提供有关基因及其调控相互作用的全面详细信息，例如基因描述、核苷酸序列、基因组链位置和与其他数据库的链接以及它所施加的调控类型或它所受到的影响（抑制或激活）、相关的实验证据和参考文献以及拓扑信息。此外，RegulomePA 提供了一种恢复基因所属网络调节电路信息的方法，并且还提供源代码来分析任何其他调节网络的拓扑。我们的团队将在我们自己和用户的贡献下每年更新该数据库，因为为用户提供了一个互动平台，他们可以在其中向监管网络添加互动，为其提供各自的参考资料。