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Towards a unified open access dataset of molecular interactions
Nature Communications ( IF 16.6 ) Pub Date : 2020-12-01 , DOI: 10.1038/s41467-020-19942-z
Pablo Porras 1 , Elisabet Barrera 1 , Alan Bridge 2 , Noemi Del-Toro 1 , Gianni Cesareni 3, 4 , Margaret Duesbury 1, 5 , Henning Hermjakob 1 , Marta Iannuccelli 3 , Igor Jurisica 6, 7, 8 , Max Kotlyar 6 , Luana Licata 3 , Ruth C Lovering 9 , David J Lynn 10, 11 , Birgit Meldal 1 , Bindu Nanduri 12 , Kalpana Paneerselvam 1 , Simona Panni 13 , Chiara Pastrello 6 , Matteo Pellegrini 14 , Livia Perfetto 1 , Negin Rahimzadeh 5 , Prashansa Ratan 5 , Sylvie Ricard-Blum 15 , Lukasz Salwinski 5 , Gautam Shirodkar 5 , Anjalia Shrivastava 1, 16 , Sandra Orchard 1
Affiliation  

The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.



中文翻译:

迈向分子相互作用的统一开放存取数据集

国际分子交换 (IMEx) 联盟为科学家提供一整套经过实验验证的蛋白质相互作用,这些相互作用在丰富的背景细节中符合国际公认的标准。在对 IMEx 联盟工作的这次更新中,我们讨论了该计划如何在实践中发挥作用,它如何确保数据库的可持续性,以及它如何通过引入新的交互器类型和数据格式来应对新出现的注释挑战。此外,我们还提供了生物医学研究人员如何使用 IMEx 数据以及如何将其集成到其他生物信息学工具和资源中的示例。

更新日期:2020-12-01
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