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Correlation of bronchoalveolar lavage lymphocyte count with the extent of lung fibrosis and with plethysmographic lung volumes in patients with newly recognized hypersensitivity pneumonitis
Central European Journal of Immunology ( IF 1.5 ) Pub Date : 2020-11-01 , DOI: 10.5114/ceji.2020.101246 Monika Szturmowicz 1 , Inga BaraŃska 2 , Agnieszka Skoczylas 3 , MaŁgorzata E JĘdrych 1 , Urszula Demkow 4
Central European Journal of Immunology ( IF 1.5 ) Pub Date : 2020-11-01 , DOI: 10.5114/ceji.2020.101246 Monika Szturmowicz 1 , Inga BaraŃska 2 , Agnieszka Skoczylas 3 , MaŁgorzata E JĘdrych 1 , Urszula Demkow 4
Affiliation
Introduction
Hypersensitivity pneumonitis (HP) is an increasingly recognized interstitial lung disease, presenting with elevated total cell counts and high percentage of lymphocytes in bronchoalveolar lavage fluid (BALF). Despite many publications, there is no consensus in the literature concerning BALF cellular composition in patients with prolonged course of HP.
Aim
The aim of the present retrospective study was to investigate the influence of disease duration, smoking habits, and the extent of lung fibrosis on BALF cells’ population in patients with newly recognized HP.
Material and methods
In total, 94 patients (49 females, 45 males), mean age 52 (±12) years, with HP recognized according to recently proposed criteria, were enrolled into the present study. Chest CT scans were retrospectively reviewed by two independent radiologists. BALF evaluation was performed as a part of routine diagnostics according to recent recommendations.
Results
Percentage of lymphocytes in BALF was significantly lower in patients with lung fibrosis (stage 1 and 2) comparing to those without lung fibrosis (stage 0). Significant correlation was also found between the percentage of BALF lymphocytes and plethysmographic lung volumes, but not with lung transfer capacity for carbon monoxide (TLCO% pred). Smoking did not influence BALF results in our study group.
Conclusions
BALF lymphocytosis correlated with the presence and the extent of lung fibrosis on chest CT as well as with plethysmographic lung volumes but did not with TLCO and smoking habits in newly recognized HP pneumonitis.
中文翻译：
新发现的过敏性肺炎患者支气管肺泡灌洗淋巴细胞计数与肺纤维化程度和体积描记肺容积的相关性
简介
过敏性肺炎 (HP) 是一种越来越多的间质性肺病，表现为支气管肺泡灌洗液 (BALF) 中总细胞计数升高和淋巴细胞百分比升高。尽管发表了许多文章，但文献中关于 HP 病程延长患者的 BALF 细胞组成尚未达成共识。
目的
本回顾性研究的目的是调查疾病持续时间、吸烟习惯和肺纤维化程度对新发现的 HP 患者 BALF 细胞群的影响。
材料与方法
总共有 94 名患者（49 名女性，45 名男性），平均年龄 52 (±12) 岁，根据最近提出的标准确认为 HP，被纳入本研究。胸部 CT 扫描由两名独立放射科医师回顾性审查。根据最近的建议，BALF 评估作为常规诊断的一部分进行。
结果
肺纤维化患者（1 期和 2 期）的 BALF 淋巴细胞百分比显着低于无肺纤维化患者（0 期）。在 BALF 淋巴细胞百分比和体积描记肺容积之间也发现了显着相关性，但与一氧化碳的肺转移能力 (TLCO% pred) 无关。在我们的研究组中，吸烟不影响 BALF 结果。
结论
BALF 淋巴细胞增多与胸部 CT 上肺纤维化的存在和程度以及体积描记肺容积相关，但与新发现的 HP 肺炎中的 TLCO 和吸烟习惯无关。
更新日期：2020-12-01
Hypersensitivity pneumonitis (HP) is an increasingly recognized interstitial lung disease, presenting with elevated total cell counts and high percentage of lymphocytes in bronchoalveolar lavage fluid (BALF). Despite many publications, there is no consensus in the literature concerning BALF cellular composition in patients with prolonged course of HP.
Aim
The aim of the present retrospective study was to investigate the influence of disease duration, smoking habits, and the extent of lung fibrosis on BALF cells’ population in patients with newly recognized HP.
Material and methods
In total, 94 patients (49 females, 45 males), mean age 52 (±12) years, with HP recognized according to recently proposed criteria, were enrolled into the present study. Chest CT scans were retrospectively reviewed by two independent radiologists. BALF evaluation was performed as a part of routine diagnostics according to recent recommendations.
Results
Percentage of lymphocytes in BALF was significantly lower in patients with lung fibrosis (stage 1 and 2) comparing to those without lung fibrosis (stage 0). Significant correlation was also found between the percentage of BALF lymphocytes and plethysmographic lung volumes, but not with lung transfer capacity for carbon monoxide (TLCO% pred). Smoking did not influence BALF results in our study group.
Conclusions
BALF lymphocytosis correlated with the presence and the extent of lung fibrosis on chest CT as well as with plethysmographic lung volumes but did not with TLCO and smoking habits in newly recognized HP pneumonitis.
中文翻译：
新发现的过敏性肺炎患者支气管肺泡灌洗淋巴细胞计数与肺纤维化程度和体积描记肺容积的相关性
简介
过敏性肺炎 (HP) 是一种越来越多的间质性肺病，表现为支气管肺泡灌洗液 (BALF) 中总细胞计数升高和淋巴细胞百分比升高。尽管发表了许多文章，但文献中关于 HP 病程延长患者的 BALF 细胞组成尚未达成共识。
目的
本回顾性研究的目的是调查疾病持续时间、吸烟习惯和肺纤维化程度对新发现的 HP 患者 BALF 细胞群的影响。
材料与方法
总共有 94 名患者（49 名女性，45 名男性），平均年龄 52 (±12) 岁，根据最近提出的标准确认为 HP，被纳入本研究。胸部 CT 扫描由两名独立放射科医师回顾性审查。根据最近的建议，BALF 评估作为常规诊断的一部分进行。
结果
肺纤维化患者（1 期和 2 期）的 BALF 淋巴细胞百分比显着低于无肺纤维化患者（0 期）。在 BALF 淋巴细胞百分比和体积描记肺容积之间也发现了显着相关性，但与一氧化碳的肺转移能力 (TLCO% pred) 无关。在我们的研究组中，吸烟不影响 BALF 结果。
结论
BALF 淋巴细胞增多与胸部 CT 上肺纤维化的存在和程度以及体积描记肺容积相关，但与新发现的 HP 肺炎中的 TLCO 和吸烟习惯无关。
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