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Natural killer frequency determines natural killer cytotoxicity directly in accentuated zones and indirectly in “moderate-to-normal frequency” segment
Central European Journal of Immunology ( IF 1.5 ) Pub Date : 2020-11-01 , DOI: 10.5114/ceji.2020.101263 Boris Dons’koi , Victor P. Chernyshov , Dariia V. Osypchuk , Iryna Sudoma , Kseniia G. Khazhylenko , Galina V. Strelko , Wera J. Sirenko
Central European Journal of Immunology ( IF 1.5 ) Pub Date : 2020-11-01 , DOI: 10.5114/ceji.2020.101263 Boris Dons’koi , Victor P. Chernyshov , Dariia V. Osypchuk , Iryna Sudoma , Kseniia G. Khazhylenko , Galina V. Strelko , Wera J. Sirenko
Natural killer (NK) frequency and NK cytotoxicity (NKc) are key determining factors of a clinical outcome. In our previous study, we showed the prognostic clinical significance of immune parameters when they are beyond the optimal range (accentuated). In this study, we attempted to explain the disparity of accentuated but physiologically and immunologically normal NK parameters that might serve as negative clinical prognostics indications of failed pregnancies. We have analyzed NK%, NKc levels, and their reciprocal correlation in 2,804 patients with reproductive failures.
In the entire clinical population, NK% correlates with NKc. Interestingly, we found this relationship to be strongly dependent on NK level’s status. NK%-NKc correlation was the strongest (r = 0.2021, p < 0.0001) in a patient group with high NK% (> 17.5%). Patients with NK% between 15-17.5% manifested lower but still significant correlation NK%-NKc (r = 0.1213, p = 0.0155). Additionally, significant correlation (r = 0.2689, p < < 0.0001) between NK% and NKc was observed in a group of patients with NK levels < 7% (1.7-7%). While patients’ groups with NK% (7-15%) did not reveal NK%-NKc association.
This led us to hypothesize that the qualitative-quantitative status of NK population is responsible for their cytotoxic activity. Consistent with our hypothesis, the “balanced zone” NK% is tightly controlled, and thus does not correlate directly with NKc. In contrast, the “accentuated zones” of NK% escape this control and directly affecting NKc. Demonstrated phenomena supports our idea about the clinical significance of immune accentuation and explains its novel physiological role.
中文翻译：
天然杀伤频率直接在重点区域和“中度至正常频率”部分间接确定天然杀伤细胞的细胞毒性
天然杀手（NK）频率和NK细胞毒性（NKc）是临床结果的关键决定因素。在我们以前的研究中，我们显示了免疫参数超出最佳范围（加重）时的预后临床意义。在这项研究中，我们试图解释加重但生理和免疫上正常的NK参数的差异，这些差异可能是妊娠失败的临床预后阴性指标。我们分析了2804例生殖功能衰竭患者的NK％，NKc水平及其相互关系。
在整个临床人群中，NK％与NKc相关。有趣的是，我们发现这种关系在很大程度上取决于NK水平的状态。在NK％高（> 17.5％）的患者组中，NK％-NKc相关性最强（r = 0.2021，p <0.0001）。NK％在15-17.5％之间的患者表现出较低但仍显着相关的NK％-NKc（r = 0.1213，p = 0.0155）。此外，在一组NK水平<7％（1.7-7％）的患者中，NK％和NKc之间存在显着相关性（r = 0.2689，p <<0.0001）。NK％（7-15％）的患者组未显示NK％-NKc的相关性。
这使我们假设NK群体的定性和定量状态与其细胞毒活性有关。与我们的假设一致，“平衡区” NK％受严格控制，因此与NKc不直接相关。相反，NK％的“突出区”逃避了这种控制，直接影响了NKc。所证实的现象支持了我们关于免疫增强的临床意义的观点，并解释了其新的生理作用。
更新日期：2020-12-01
In the entire clinical population, NK% correlates with NKc. Interestingly, we found this relationship to be strongly dependent on NK level’s status. NK%-NKc correlation was the strongest (r = 0.2021, p < 0.0001) in a patient group with high NK% (> 17.5%). Patients with NK% between 15-17.5% manifested lower but still significant correlation NK%-NKc (r = 0.1213, p = 0.0155). Additionally, significant correlation (r = 0.2689, p < < 0.0001) between NK% and NKc was observed in a group of patients with NK levels < 7% (1.7-7%). While patients’ groups with NK% (7-15%) did not reveal NK%-NKc association.
This led us to hypothesize that the qualitative-quantitative status of NK population is responsible for their cytotoxic activity. Consistent with our hypothesis, the “balanced zone” NK% is tightly controlled, and thus does not correlate directly with NKc. In contrast, the “accentuated zones” of NK% escape this control and directly affecting NKc. Demonstrated phenomena supports our idea about the clinical significance of immune accentuation and explains its novel physiological role.
中文翻译：
天然杀伤频率直接在重点区域和“中度至正常频率”部分间接确定天然杀伤细胞的细胞毒性
天然杀手（NK）频率和NK细胞毒性（NKc）是临床结果的关键决定因素。在我们以前的研究中，我们显示了免疫参数超出最佳范围（加重）时的预后临床意义。在这项研究中，我们试图解释加重但生理和免疫上正常的NK参数的差异，这些差异可能是妊娠失败的临床预后阴性指标。我们分析了2804例生殖功能衰竭患者的NK％，NKc水平及其相互关系。
在整个临床人群中，NK％与NKc相关。有趣的是，我们发现这种关系在很大程度上取决于NK水平的状态。在NK％高（> 17.5％）的患者组中，NK％-NKc相关性最强（r = 0.2021，p <0.0001）。NK％在15-17.5％之间的患者表现出较低但仍显着相关的NK％-NKc（r = 0.1213，p = 0.0155）。此外，在一组NK水平<7％（1.7-7％）的患者中，NK％和NKc之间存在显着相关性（r = 0.2689，p <<0.0001）。NK％（7-15％）的患者组未显示NK％-NKc的相关性。
这使我们假设NK群体的定性和定量状态与其细胞毒活性有关。与我们的假设一致，“平衡区” NK％受严格控制，因此与NKc不直接相关。相反，NK％的“突出区”逃避了这种控制，直接影响了NKc。所证实的现象支持了我们关于免疫增强的临床意义的观点，并解释了其新的生理作用。
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