Abstract

Background

Advancements in medical technologies that utilize ionizing radiation have led to improved diagnosis and patient outcomes, however, the effect of ionizing radiation on the patient is still debated. In the case of pregnancy, the potential effects are not only to the mother but also to the fetus. The aim of this study was to determine if exposure from ionizing radiation during pregnancy alters the development of the cardiovascular and respiratory system of the offspring.

Materials and methods

Pregnant C57Bl/6 mice were whole-body irradiated at gestational day 15 with a ¹³⁷Cs gamma radiation emitting source at 0 mGy (sham), 50 mGy, 300 mGy, or 1000 mGy. Post weaning weight and blood pressure measurements were taken weekly for both male and female pups until euthanasia at 16–17 weeks postnatal age. Immediately following, the trachea was cannulated, and the lungs and heart excised. The lung was then examined to assess respiratory physiological outcomes.

Results and conclusions

In utero exposures to 1000 mGy caused significant growth reduction compared to sham irradiated, which remained persistent for both male and female pups. Growth restriction was not observed for lower exposures. There was no significant change in any cardiovascular or respiratory outcomes measured. Overall, intrauterine exposures to ionizing radiation does not appear to significantly alter the development of the cardiovascular and respiratory system in C57Bl/6 pups up to 17 weeks postnatal age.

中文翻译：

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子宫内暴露于电离辐射后，健康 C57Bl/6 小鼠的心血管和呼吸系统结果不变

摘要

背景

利用电离辐射的医疗技术的进步已经改善了诊断和患者预后，但是，电离辐射对患者的影响仍然存在争议。在怀孕的情况下，潜在的影响不仅对母亲而且对胎儿。本研究的目的是确定怀孕期间接触电离辐射是否会改变后代心血管和呼吸系统的发育。

材料和方法

怀孕的 C57Bl/6 小鼠在妊娠第 15 天用0 mGy（假手术）、50 mGy、300 mGy 或 1000 mGy的¹³⁷ Cs γ 辐射源进行全身照射。每周对雄性和雌性幼崽进行断奶后体重和血压测量，直到出生后 16-17 周进行安乐死。紧接着，气管被插管，肺和心脏被切除。然后检查肺以评估呼吸生理结果。

结果和结论

与假辐照相比，在子宫内暴露于 1000 mGy 会导致生长显着减少，这对于雄性和雌性幼崽来说都是持续存在的。较低暴露未观察到生长受限。测量的任何心血管或呼吸系统结果都没有显着变化。总体而言，宫内暴露于电离辐射似乎不会显着改变出生后 17 周龄的 C57Bl/6 幼崽的心血管和呼吸系统的发育。