ABSTRACT

This research aimed to explore in free-living condition, in healthy normal weight subjects, the effect of social jetlag (SJL) and sleep deprivation on resting-state brain connectivity and synchronization, as assessed by resting-state fMRI, and their association with appetite. We found abnormal local functional synchronization in resting-state, as depicted by altered regional homogeneity (ReHo), in posterior cerebellar regions in subjects with SJL and/or sleep deprivation. We also found altered intrinsic global connectivity patterns, as depicted by altered degree of centrality (DC), in cerebellar regions in these subjects. In our sample, ReHo was correlated with appetite in fasting state in subjects with SJL and in those with sleep deprivation, while DC was correlated with appetite only in subjects with SJL. The effect size evaluation showed that 21.1% to 35.7% of the variance in appetite of subjects with SJL was explained by altered ReHo and DC; in subjects with sleep deprivation 21.2% to 61.3% of the variance in appetite was explained by altered ReHo. This analysis provides the first evidence of abnormal resting-state local functional synchronization and intrinsic global connectivity patterns in healthy subjects with SJL in real-life settings. These changes were independent of sleep deprivation and correlated with appetite.

摘要

本研究旨在探索在自由生活条件下，在健康正常体重的受试者中，社交时差 (SJL) 和睡眠剥夺对静息状态大脑连接和同步的影响（通过静息状态 fMRI 评估）及其与食欲的关系. 我们在 SJL 和/或睡眠剥夺受试者的小脑后部区域发现了静息状态下异常的局部功能同步，如区域同质性改变 (ReHo) 所示。我们还在这些受试者的小脑区域发现了改变的内在全局连接模式，如改变的中心度 (DC) 所示。在我们的样本中，ReHo 与 SJL 受试者和睡眠剥夺受试者在禁食状态下的食欲相关，而 DC 仅与 SJL 受试者的食欲相关。效应量评估表明，SJL 受试者的食欲差异中有 21.1% 至 35.7% 可以通过改变的 ReHo 和 DC 来解释；在睡眠剥夺的受试者中，21.2% 到 61.3% 的食欲变化可以通过改变的 ReHo 来解释。该分析提供了在现实生活环境中 SJL 健康受试者异常静息状态局部功能同步和内在全局连接模式的第一个证据。这些变化与睡眠剥夺无关，与食欲相关。该分析提供了在现实生活环境中 SJL 健康受试者异常静息状态局部功能同步和内在全局连接模式的第一个证据。这些变化与睡眠剥夺无关，与食欲相关。该分析提供了在现实生活环境中 SJL 健康受试者异常静息状态局部功能同步和内在全局连接模式的第一个证据。这些变化与睡眠剥夺无关，与食欲相关。