Abstract

As the most important innate immune component cancers invader, natural killer (NK) cells have a magnificent role in antitumor immunity without any prior sensitization. Different subsets of NK cells have distinct responses during tumor cell exposure, according to their phenotypes and environments. Their function is induced mainly by the activity of both inhibitory and activating receptors against cancerous cells. Since the immunosuppression in the tumor microenvironment of breast cancer patients has directly deteriorated the phenotype and disturbed the function of NK cells, recruiting compensatory mechanisms indicate promising outcomes for immunotherapeutic approaches. These evidences accentuate the importance of NK cell distinct features in protection against breast tumors. In this review, we discuss the several mechanisms involved in NK cells suppression which consequently promote tumor progression and disease recurrence in patients with breast cancer.

摘要

作为最重要的先天免疫成分癌症入侵者，自然杀伤 (NK) 细胞在没有任何预先致敏的情况下在抗肿瘤免疫中发挥着巨大的作用。根据它们的表型和环境，不同的 NK 细胞亚群在肿瘤细胞暴露期间具有不同的反应。它们的功能主要是由抑制性和激活性受体对癌细胞的活性诱导的。由于乳腺癌患者肿瘤微环境中的免疫抑制直接恶化了 NK 细胞的表型并扰乱了 NK 细胞的功能，因此招募补偿机制表明免疫治疗方法有希望的结果。这些证据强调了 NK 细胞独特特征在预防乳腺肿瘤方面的重要性。在这次审查中，