A comprehensive human minimal gut metagenome extends the host’s metabolic potential,Microbial Genomics

当前位置： X-MOL 学术 › Microb. Genom. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A comprehensive human minimal gut metagenome extends the host’s metabolic potential
Microbial Genomics ( IF 4.0 ) Pub Date : 2020-11-01 , DOI: 10.1099/mgen.0.000466
Marcos Parras-Moltó ₁ , Daniel Aguirre de Cárcer ₁

Affiliation

Accumulating evidence suggests that humans could be considered as holobionts in which the gut microbiota play essential functions. Initial metagenomic studies reported a pattern of shared genes in the gut microbiome of different individuals, leading to the definition of the minimal gut metagenome as the set of microbial genes necessary for homeostasis and present in all healthy individuals. This study analyses the minimal gut metagenome of the most comprehensive dataset available, including individuals from agriculturalist and industrialist societies, also embodying highly diverse ethnic and geographical backgrounds. The outcome, based on metagenomic predictions for community composition data, resulted in a minimal metagenome comprising 3412 genes, mapping to 1856 reactions and 128 metabolic pathways predicted to occur across all individuals. These results were substantiated by the analysis of two additional datasets describing the microbial community compositions of larger Western cohorts, as well as a substantial shotgun metagenomics dataset. Subsequent analyses showed the plausible metabolic complementarity provided by the minimal gut metagenome to the human genome.

更新日期：2020-12-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文