In the late 1990s, Se-Jin Lee was exploring the effects of regulatory genes in mice when he found a gene with a remarkable phenotype (1). “These mice have a doubling of muscle mass throughout the body,” says Lee. He had been identifying and characterizing new members of the TGF-β family of signaling proteins that he called growth/differentiation factors (GDFs) and had knocked out various GDFs in mice, including GDF8. “When we knocked it out, it turned out to have this hypermuscular phenotype,” says Lee.

中文翻译：

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李世进的个人资料[个人资料]

在1990年代后期，李世进发现了具有显着表型的基因时，正在探索调节基因在小鼠中的作用（1）。“这些小鼠的全身肌肉质量增加了一倍，” Lee说。他一直在鉴定和表征TGF-β信号蛋白家族的新成员，他称其为生长/分化因子（GDF），并敲除了小鼠中的各种GDF，包括GDF8。Lee说：“当我们将其剔除后，就证明具有这种超肌肉表型。”