The emergence of “superbugs” resistant to antimicrobial medications threatens populations both veterinary and human. The current crisis has come about from the widespread use of the limited number of antimicrobials available in the treatment of livestock, companion animal, and human patients. A different approach must be sought to find alternatives to or enhancements of present conventional antimicrobials. Mesenchymal stromal cells (MSC) have antimicrobial properties that may help solve this problem. In the first part of the review, we explore the various mechanisms at work across species that help explain how MSCs influence microbial survival. We then discuss the findings of recent equine, canine, and bovine studies examining MSC antimicrobial properties in which MSCs are found to have significant effects on a variety of bacterial species either alone or in combination with antibiotics. Finally, information on the influence that various antimicrobials may have on MSC function is reviewed. MSCs exert their effect directly through the secretion of various bioactive factors or indirectly through the recruitment and activation of host immune cells. MSCs may soon become a valuable tool for veterinarians treating antimicrobial resistant infections. However, a great deal of work remains for the development of optimal MSC production conditions and testing for efficacy on different indications and species.

对抗菌药物产生抗药性的“超级细菌”的出现威胁着兽医和人类。当前的危机是由于在牲畜，伴侣动物和人类患者的治疗中广泛使用有限数量的抗菌剂而引起的。必须寻求一种不同的方法来找到当前常规抗菌剂的替代品或增强剂。间充质基质细胞（MSC）具有抗菌特性，可以帮助解决此问题。在审查的第一部分中，我们探索了跨物种工作的各种机制，这些机制有助于解释MSC如何影响微生物存活。然后，我们讨论最近的马，犬，一项关于MSC抗菌特性的牛研究，其中发现MSC单独或与抗生素联合使用对多种细菌具有显着影响。最后，回顾了有关各种抗菌素可能对MSC功能产生影响的信息。MSC通过分泌各种生物活性因子直接发挥作用，或通过宿主免疫细胞的募集和激活间接发挥作用。MSC可能很快成为兽医治疗抗药性感染的重要工具。但是，仍然需要大量工作来开发最佳的MSC生产条件并测试不同适应症和物种的功效。MSC通过分泌各种生物活性因子直接发挥作用，或通过宿主免疫细胞的募集和激活间接发挥作用。MSC可能很快成为兽医治疗抗药性感染的重要工具。但是，仍然需要大量工作来开发最佳的MSC生产条件并测试不同适应症和物种的功效。MSC通过分泌各种生物活性因子直接发挥作用，或通过宿主免疫细胞的募集和激活间接发挥作用。MSC可能很快成为兽医治疗抗药性感染的重要工具。但是，仍然需要大量工作来开发最佳的MSC生产条件并测试不同适应症和物种的功效。