The pharmacokinetics of fluoroquinolones in chelonians are well described but this does not extend to pradofloxacin, a broad-spectrum veterinary fluoroquinolone available as an oral suspension for cats and dogs. The aim of this study was to investigate the single-dose pharmacokinetic profile of pradofloxacin oral suspension at 7.5 mg/kg in eastern long-necked turtles (Chelodina longicollis). Eight treated turtles were sampled at multiple time points up to 168 hr. Plasma concentrations were measured using high-performance liquid chromatography. Pradofloxacin was quantifiable for up to 48 hr after drug administration. The T_max (9.0 hr) and T_½ to 48 hr (13.16 hr) were longer, and the C_max (0.2 μg/ml) and AUC_0-24 (2.2 hr*μg/ml) lower, than previously reported in cats and dogs. Pradofloxacin was measurable in tank water samples for up to 48 hr. No adverse effects were observed in six turtles administered 7.5 mg/kg sid for 7 days. Using mammalian MIC data, the AUC_0-24/MIC ratios for a range of bacterial isolates suggest that this dose of pradofloxacin in turtles is unlikely to be effective against many bacterial pathogens.

中文翻译：

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东方长颈龟（Chelodina longicollis）单剂量口服普多沙星混悬液的药代动力学特征

氟喹诺酮类药物在龟类中的药代动力学已得到很好的描述，但并未延伸到普多沙星，这是一种广谱兽用氟喹诺酮类药物，可作为猫和​​狗的口服混悬液使用。本研究的目的是研究 7.5 mg/kg 的普多沙星口服混悬剂在东部长颈龟 ( Chelodina longicollis ) 中的单剂量药代动力学特征。在长达 168 小时的多个时间点对八只处理过的海龟进行了采样。使用高效液相色谱法测量血浆浓度。普多沙星在给药后长达 48 小时内可量化。T _max (9.0 hr) 和 T _½至 48 hr (13.16 hr) 更长，C _max (0.2 μg/ml) 和 AUC _0-24(2.2 hr*μg/ml) 低于之前在猫和狗中报道的。普多沙星可在水箱水样中测量长达 48 小时。在 7 天服用 7.5 mg/kg sid 的六只海龟中未观察到不良反应。使用哺乳动物 MIC 数据，一系列细菌分离物的 AUC _{0-24 /MIC 比率表明，这种剂量的普多沙星在海龟中不太可能对许多细菌病原体有效。}