Objective

The purpose of this article is to review the pathophysiologic mechanisms, differential diagnosis, evaluation, and treatment of the various manifestations of ocular allergy, with an especial focus on immunoglobulin E (IgE)-mediated disease.

Data Sources

A PubMed search was performed to include articles, using the search terms ocular allergy and allergic conjunctivitis.

Study Selections

Recent and relevant human studies in the English language pertaining to our topic of study were selected. Animal studies pertaining to pathophysiology of ocular allergy were also reviewed. We focused on clinical trials, practice guidelines, reviews, and systematic reviews. In addition, case reports were reviewed if they described rare clinical presentations, disease mechanisms, or novel therapies.

Results

Ocular allergy encompasses both IgE- and non–IgE-mediated disease, and the clinical severity may range from mild to sight-threatening inflammation. A comprehensive treatment regimen including education, lifestyle measures, topical therapies, and even systemic interventions may be necessary for the effective management of ocular allergies, tailored according to symptom severity.

Conclusion

Ocular allergy is frequently encountered by allergists and eye-care specialists, and despite progressively increasing incidence, it often remains underdiagnosed and, hence, untreated.

中文翻译：

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过敏性眼病的范围

客观的

本文的目的是回顾眼部过敏的各种表现的病理生理机制，鉴别诊断，评估和治疗，特别是针对免疫球蛋白E（IgE）介导的疾病。

数据源

使用搜索词眼变态反应和过敏性结膜炎，进行PubMed搜索以包括文章。

研究选择

选择了与我们的学习主题相关的英语近期和相关人类研究。还审查了有关眼过敏病理生理的动物研究。我们专注于临床试验，实践指南，评价和系统评价。此外，如果病例报告描述了罕见的临床表现，疾病机制或新疗法，则对其进行回顾。

结果

眼部过敏既包括IgE介导的疾病，也包括非IgE介导的疾病，其临床严重程度可能从轻度到威胁视力的炎症不等。为了有效管理眼部过敏，可能需要根据症状严重程度而定的综合治疗方案，包括教育，生活方式措施，局部疗法，甚至系统干预。

结论

过敏症和眼保健专家经常遇到眼部过敏，尽管发病率逐渐增加，但常常仍未得到充分诊断，因此未经治疗。