Photothermal sensors represent a novel type of probe having potential in the field of clinical diagnostics particularly due to the lack of a tedious sample pre-treatment, a sophisticated equipment and a skilled manpower. Herein, we describe the fabrication of a microfluidic nickel-resistive temperature detector (micro-Ni-RTD) for the selective monitoring of diabetes using a boronate-based sialic acid (SA) receptor. This work represents an improvement made to our previous photothermal sensor designs by reducing the cost by about 100-fold and significantly improving the sensitivity of the device, enabling the detection of sialic acid contents as low as 0.06 μmol/mL, a 4-fold improvement compared to the sensor described our previous study. The average temperature difference between healthy subjects and diabetes patients was found to be 0.181 °C dL/g with micro-Ni-RTD in comparison with 0.043 °C dL/g with our previous platinum-based resistive temperature detector (Pt-RTD) reported previously The enhancement in the discriminatory ability of micro-Ni-RTD for the diabetic clinical samples compared with healthy control can be attributed to the modified surface modification strategy and the incorporation of the microfluidic channels. Thus, micro-Ni-RTD represents a convenient, rapid, reliable, and low-cost biosensor for the clinical monitoring of diabetes patients.

光热传感器代表了一种新型的探针，在临床诊断领域具有潜力，特别是由于缺少乏味的样品预处理，复杂的设备和熟练的人力。在这里，我们描述了使用基于硼酸盐的唾液酸（SA）受体选择性监测糖尿病的微流控镍电阻温度检测器（micro-Ni-RTD）的制造。这项工作是对我们以前的光热传感器设计的改进，将成本降低了约100倍，并显着提高了设备​​的灵敏度，使唾液酸含量低至0.06μmol/ mL，可提高4倍。与我们先前研究中描述的传感器相比。发现健康受试者与糖尿病患者之间的平均温度差为0。之前报道了使用微型Ni-RTD的181°C dL / g，而使用我们先前的铂基电阻温度检测器（Pt-RTD）的0.043°C dL / g的结果微型Ni-RTD的鉴别能力有所提高与健康对照相比，糖尿病临床样品可归因于改良的表面修饰策略和微流体通道的整合。因此，微型Ni-RTD代表了一种方便，快速，可靠且低成本的生物传感器，用于糖尿病患者的临床监测。先前报道的我们先前的铂基电阻温度检测器（Pt-RTD）的043°C dL / g与健康对照组相比，微镍镍RTD对糖尿病临床样品的辨别能力增强可归因于表面改性修饰策略和微流体通道的整合。因此，微型Ni-RTD代表了一种方便，快速，可靠且低成本的生物传感器，用于糖尿病患者的临床监测。先前报道的我们先前的铂基电阻温度检测器（Pt-RTD）的043°C dL / g与健康对照组相比，微镍镍RTD对糖尿病临床样品的辨别能力增强可归因于表面改性修饰策略和微流体通道的整合。因此，微型Ni-RTD代表了一种方便，快速，可靠且低成本的生物传感器，用于糖尿病患者的临床监测。