Study Objective

To investigate the etiology, progression, and treatment of precocious puberty in 7- to 8-year-old girls with breast development. Additionally, we evaluated the value of diagnostic tests in differentiating rapidly progressive precocious puberty (RP-PP) and slowly progressive precocious puberty (SP-PP) in these girls.

Design

Ambispective cohort study.

Setting

Single-center, pediatric endocrinology unit.

Participants

Girls with breast development between the ages of 7 and 8 years and assessed between July 2016 and July 2018.

Interventions

Collected of clinical data and followed-up for 2 to 3 years. Girls were divided into RP-PP and SP-PP groups.

Main Outcome Measures

Described the etiology, rate of progression of puberty, and proportion intervened and compared the results of auxiliary examinations between the groups.

Results

A total of 212 girls were enrolled, of which 211 (99.53%) were diagnosed with central precocious puberty (CPP) and 1 with peripheral precocious puberty (PPP). Hypophysis magnetic resonance imaging revealed that none had pathological brain lesions requiring surgical intervention. A total of 95 girls (44.81%) developed RP-PP, and 117 girls (55.19%) developed SP-PP. A total of 31 girls (14.62%) with RP-PP received treatment due to deteriorated predicting adult height. As compared with the SP-PP group, the RP-PP group showed more advanced bone age (BA), a higher level of basal luteinizing hormone (LH), and larger ovarian volume and uterine volumes. Receiver operating characteristic analyses revealed that BA was the best at identifying girls with RP-PP.

Conclusion

The majority of girls with breast development between the ages of 7-8 years do not need treatment. BA is a useful preliminary test for identifying girls with RP-PP who are more likely to require treatment.

中文翻译：

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大多数7至8岁的青春期早期女孩需要广泛的调查和治疗吗？

研究目的

调查7至8岁乳房发育女孩性早熟的病因，进展和治疗。此外，我们评估了诊断测试在区分这些女孩的快速进行性早熟（RP-PP）和缓慢进行性早熟（SP-PP）中的价值。

设计

队列研究。

环境

单中心小儿内分泌科。

参加者

在2016年7月至2018年7月之间评估了7至8岁之间乳房发育的女孩。

干预措施

收集临床资料并随访2至3年。女孩分为RP-PP和SP-PP组。

主要观察指标

描述病因，青春期进展率和干预比例，并比较两组间辅助检查的结果。

结果

总共招募了212名女孩，其中211名（99.53％）被诊断为中枢性早熟（CPP），其中1名被诊断为外周性早熟（PPP）。垂体磁共振成像显示，没有人患有需要手术干预的病理性脑损伤。共有95名女孩（占44.81％）开发了RP-PP，117名女孩（占55.19％）开发了SP-PP。由于预测的成人身高恶化，共有31名女孩（14.62％）接受了RP-PP治疗。与SP-PP组相比，RP-PP组显示更年长的骨龄（BA），更高的基础黄体生成激素（LH）水平以及更大的卵巢和子宫体积。接收者的工作特征分析表明，BA最适合识别RP-PP的女孩。

结论

大多数7-8岁之间乳房发育的女孩不需要治疗。BA是一项有用的初步测试，可用于识别更可能需要治疗的RP-PP女孩。