Synthesis and characterisation of the first macrocyclic Cu(I), Ag(I) and Au(I) tricarbene/urea N-heterocyclic carbene (NHC) complexes is described and their fluorescence properties are compared to related tetracarbene complexes. The newly described silver and gold complexes show luminescence with emission maxima at λ_em,max = 481 nm and λ_em,max = 334 nm, respectively. Moreover, their ability to inhibit the growth of bacteria (S. aureus and E. coli) and cancer cells (HeLa and MCF7) is investigated. A strong influence of the metal is observed. While the copper and gold complexes are inactive against bacteria, the silver complex depicts a moderate activity (MIC ≈ 30 µM). The copper and silver complexes exhibit antiproliferative activity in both cell lines, ranging from 25.1 µM to 3.03 µM.

描述了第一大环Cu（I），Ag（I）和Au（I）三卡宾/脲N-杂环卡宾（NHC）配合物的合成和表征，并将其荧光性质与相关的四卡宾配合物进行了比较。新近描述的银和金配合物显示出发光，其发射最大值分别在_λem，max  = 481 nm和_λem，max  = 334 nm处。而且，它们具有抑制细菌（金黄色葡萄球菌和大肠杆菌）生长的能力。）和癌细胞（HeLa和MCF7）进行了研究。观察到金属的强烈影响。铜和金配合物对细菌没有活性，而银配合物表现出中等活性（MIC≈30 µM）。铜和银配合物在两种细胞系中均表现出抗增殖活性，范围为25.1 µM至3.03 µM。