Basal stem cells fuel development, homeostasis, and regeneration of the epidermis. The proliferation and fate decisions of these cells are highly regulated by their microenvironment, including the basement membrane and underlying mesenchymal cells. Basal progenitors give rise to differentiated progeny that generate the epidermal barrier. Here, we present data that differentiated progeny also regulate the proliferation, differentiation, and migration of basal progenitor cells. Using two distinct mouse lines, we found that increasing contractility of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and prevented their commitment to a hair follicle lineage. This increased contractility also impaired movement of basal progenitors during hair placode morphogenesis and diminished migration of melanoblasts. These data suggest that intra-tissue tension regulates stem cell proliferation, fate decisions, and migration and that differentiated epidermal keratinocytes are a component of the stem cell niche that regulates development and homeostasis of the skin.

基底干细胞促进表皮的发育，体内平衡和再生。这些细胞的增殖和命运决定受到它们微环境的高度调节，包括基底膜和下面的间充质细胞。基础祖细胞引起分化的后代，后者产生表皮屏障。在这里，我们提出分化后代的数据也调节基础祖细胞的增殖，分化和迁移。使用两种不同的小鼠品系，我们发现分化细胞的收缩力增加导致干细胞非细胞自主过度增殖，并阻止了它们对毛囊谱系的承诺。这种增加的可收缩性还损害了在头发斑块形态发生过程中基础祖细胞的运动，并减少了黑素细胞的迁移。