It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al. (2020) show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting a direct link between defects in cell adhesion and lipotoxicity.

中文翻译：

---

肾脏疾病期间脂质代谢进入JAML

尚不清楚肌动蛋白细胞骨架重塑的关键调节因子影响脂质代谢的能力是否导致肾脏损伤。在本期《细胞代谢》一书中，Fu等人。（2020年）表明，类结合黏附分子（JAML）是肾小球疾病进展的新型介质，同时提示细胞黏附缺陷和脂毒性之间存在直接联系。