Two recent studies published in Nature Immunology map out the link between dysregulated mitochondrial metabolism and terminal exhaustion of tumor-infiltrating T lymphocytes. Yu et al. (2020) and Vardhana et al. (2020) show that defective mitophagy or impaired oxidative phosphorylation triggers mitochondrial reactive oxygen species production, which in turn promotes a T cell exhaustion program, limiting T cell proliferation and self-renewal.

中文翻译：

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线粒体损害与疲劳之路

最近发表在《自然免疫学》上的两项研究勾画了线粒体代谢失调与肿瘤浸润性T淋巴细胞最终衰竭之间的联系。Yu等。（2020）和Vardhana等。（2020）表明，有缺陷的线粒体或氧化磷酸化受损触发线粒体活性氧的产生，进而促进T细胞的衰竭程序，限制T细胞的增殖和自我更新。