Childhood obesity has been linked to early puberty in girls but the mechanism(s) by which overnutrition triggers pubertal onset remain unclear. In a recent issue of Cell Metabolism, Heras et al., 2020 implicate a non-canonical central ceramide to ovarian sympathetic innervation pathway as a novel mediator of obesity-induced pubertal acceleration in female rats.

中文翻译：

---

下丘脑神经酰胺和卵巢交感系统：肥胖和青春期的十字路口

儿童肥胖与女孩青春期提前有关，但营养过剩引发青春期发作的机制仍不清楚。在最近一期的《细胞代谢》中，Heras 等人于 2020 年指出，非典型的中央神经酰胺至卵巢交感神经支配通路是肥胖引起的雌性大鼠青春期加速的新型介质。