The dependence of the level of antimicrobial activity of some ammonium isatin-3-acylhydrazones on the sterical hindrance and electronic nature of substituents in the benzyl moiety was elucidated using simple molecular descriptors and quantum chemical calculations. The structure and electronic nature of substituents in position 1 and the lipophilicity of compounds of this series were shown to be the key factors determining the activity.

中文翻译：

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取代基性质对水溶性酰基腙对靛红支架抗菌活性的影响

使用简单的分子描述符和量子化学计算阐明了某些靛红-3-酰基腙铵的抗菌活性水平对苄基部分中取代基的空间位阻和电子性质的依赖性。1 位取代基的结构和电子性质以及该系列化合物的亲油性是决定活性的关键因素。