Hydrogel development using natural and synthetic polymers for biomedical applications have shown promising properties for drug delivery due to virtuous stimuli response and improvement in mechanical strength. Biomaterial hydrogel was synthesized using combination of arabic gum (AG), a natural polymer and polyethylene glycol dimethacrylate (PEGDMA), a synthetic polymer. The synthesis process follows chemical cross linking by free radical polymerization. Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and differential scanning calorimetry (DSC) were used to characterize the hydrogels. Product yield, gel content and gelation time depends solely on the variable reacting concentrations and the mechanical properties of hydrogel depends on its compositions. Swelling studies reveal high swelling ratio in buffer solution pH 1.2 compare to buffer solution pH 7.4, and deionized water at pH 6.7. Swelling ratio raises with increase in PEGDMA concentration, but the presences of salt/ions solutions decreases the swelling ratio significantly and it depends on the charge of the ions. The kinetics of the swelling follows a second order non-linear rate equation. The rate of degradation revealed significant degradation in acidic medium and insignificant degradation was observed in basic medium. The encapsulation efficiency of quercetin introduced directly in the hydrogels during synthesis was found in the range of 85–94%. The release profile indicates the dependence of arabic gum grafted PEGDMA hydrogels on pH and compositions. The characteristic properties exhibited by the formulated hydrogels suggest the suitability of them to be applied as drug carriers.

由于良好的刺激反应和机械强度的提高，使用天然和合成聚合物进行生物医学应用的水凝胶开发已显示出令人信服的药物递送特性。生物材料水凝胶是使用阿拉伯胶（AG）（一种天然聚合物）和聚乙二醇二甲基丙烯酸酯（PEGDMA）（一种合成聚合物）的组合来合成的。合成过程通过自由基聚合进行化学交联。傅里叶变换红外光谱（FTIR），场发射扫描电子显微镜（FESEM）和差示扫描量热法（DSC）用于表征水凝胶。产品产率，凝胶含量和胶凝时间仅取决于可变的反应浓度，并且水凝胶的机械性能取决于其组成。溶胀研究表明，与pH 7.4的缓冲溶液和pH 6.7的去离子水相比，pH 1.2的缓冲溶液具有较高的溶胀率。溶胀率随PEGDMA浓度的增加而增加，但是盐/离子溶液的存在会显着降低溶胀率，这取决于离子的电荷。溶胀的动力学遵循二阶非线性速率方程。降解速率表明在酸性介质中显着降解，而在碱性介质中未见明显降解。在合成过程中直接引入水凝胶的槲皮素的包封效率为85-94％。释放曲线表明阿拉伯树胶接枝的PEGDMA水凝胶对pH和组成的依赖性。