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Drug safety profiles in geriatric patients with Parkinson’s disease using the FORTA (Fit fOR The Aged) classification: results from a mono-centric retrospective analysis
Journal of Neural Transmission ( IF 3.2 ) Pub Date : 2020-12-01 , DOI: 10.1007/s00702-020-02276-x
S Greten 1 , J I Müller-Funogea 1 , F Wegner 1 , G U Höglinger 1 , N Simon 2 , U Junius-Walker 3 , S Gerbel 2 , O Krause 3 , M Klietz 1
Affiliation  

To reduce potentially inappropriate medications, the FORTA (Fit fOR The Aged) concept classifies drugs in terms of their suitability for geriatric patients with different labels, namely A (indispensable), B (beneficial), C (questionable), and D (avoid). The aims of our study were to assess the medication appropriateness in PD inpatients applying the FORTA list and drug-drug interaction software, further to assess the adequacy of FORTA list for patients with PD. We retrospectively collected demographic data, comorbidities, laboratory values, and the medication from the discharge letters of 123 geriatric inpatients with PD at the university hospital of Hannover Medical School. Patients suffered on average from 8.2 comorbidities. The majority of the medication was labeled A (60.6% of PD-specific and 40.9% of other medication) or B (22.3% of PD-specific and 26.9% of other medication). Administered drugs labeled with D were amantadine, clozapine, oxazepam, lorazepam, amitriptyline, and clonidine. Overall, 545 interactions were identified, thereof 11.9% severe interactions, and 1.7% contraindicated combinations. 81.3% of patients had at least one moderate or severe interaction. The FORTA list gives rational recommendations for PD-specific and other medication, especially for general practitioners. Considering the demographic characteristics and the common multimorbidity of geriatric PD patients, this study underlines the importance of awareness, education, and preventive interventions to increase drug safety.



中文翻译:

使用 FORTA(适合老年人)分类的帕金森病老年患者的药物安全性概况:来自单中心回顾性分析的结果

为了减少可能不适当的药物,FORTA(适合老年人)概念根据其对老年患者的适用性对药物进行分类,具有不同的标签,即 A(必不可少)、B(有益)、C(有问题)和 D(避免) . 我们研究的目的是评估应用 FORTA 列表和药物-药物相互作用软件的 PD 住院患者的药物适宜性,进一步评估 FORTA 列表对 PD 患者的充分性。我们回顾性地收集了汉诺威医学院大学医院 123 名老年 PD 住院患者的人口统计数据、合并症、实验室值和药物治疗。患者平均患有 8.2 种合并症。大多数药物被标记为 A(60.6% 的 PD 特异性药物和 40.9% 的其他药物)或 B(22. 3% 的 PD 特异性药物和 26.9% 的其他药物)。标有 D 的给药药物是金刚烷胺、氯氮平、奥沙西泮、劳拉西泮、阿米替林和可乐定。总体而言,确定了 545 种相互作用,其中 11.9% 的严重相互作用和 1.7% 的禁忌组合。81.3% 的患者至少有一次中度或重度交互作用。FORTA 列表为 PD 特异性药物和其他药物提供了合理的建议,特别是针对全科医生。考虑到老年 PD 患者的人口学特征和常见的多种疾病,本研究强调了提高药物安全性的意识、教育和预防性干预措施的重要性。确定了 545 种相互作用,其中 11.9% 的严重相互作用和 1.7% 的禁忌组合。81.3% 的患者至少有一次中度或重度交互作用。FORTA 列表为 PD 特异性药物和其他药物提供了合理的建议,特别是针对全科医生。考虑到老年 PD 患者的人口学特征和常见的多种疾病,本研究强调了提高药物安全性的意识、教育和预防性干预措施的重要性。确定了 545 种相互作用,其中 11.9% 的严重相互作用和 1.7% 的禁忌组合。81.3% 的患者至少有一次中度或重度交互作用。FORTA 列表为 PD 特异性药物和其他药物提供了合理的建议,特别是针对全科医生。考虑到老年 PD 患者的人口学特征和常见的多种疾病,本研究强调了提高药物安全性的意识、教育和预防性干预措施的重要性。

更新日期:2020-12-01
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