Cancer is one of the healthcare problems that affect many communities around the world. Many factors contribute to cancer development. Besides, these factors are counted as the main impediment in cancer immunotherapy. Myeloid-derived suppressor cells (MDSCs) are one of these impediments. MDSCs inhibit the immune responses through various mechanisms such as inhibitory cytokine release and nitric oxide metabolite production. Several factors are involved in forming these cells, including tumor secreted cytokine and chemokines, transcription factors, and non-coding RNA. In the meantime, micro-RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the vital gene regulatory elements that affect gene expression. In this study, we are going to discuss the role of miRNAs and lncRNAs in MDSCs development in a cancer situation. It is hoped that miRNA and lncRNAs targeting may prevent the growth and development of these inhibitory cells in the cancer environment.

癌症是影响世界各地许多社区的医疗保健问题之一。许多因素会导致癌症的发展。此外，这些因素被认为是癌症免疫治疗的主要障碍。髓源性抑制细胞 (MDSC) 是这些障碍之一。MDSCs 通过多种机制抑制免疫反应，例如抑制细胞因子释放和一氧化氮代谢物的产生。这些细胞的形成涉及多种因素，包括肿瘤分泌的细胞因子和趋化因子、转录因子和非编码 RNA。同时，微小RNA（miRNA）和长链非编码RNA（lncRNA）是影响基因表达的重要基因调控元件。在这项研究中，我们将讨论 miRNA 和 lncRNA 在癌症情况下 MDSCs 发展中的作用。