Multicellular tissues are the building blocks of many biological systems and organs. These tissues are not static, but dynamically change over time. Even if the overall structure remains the same there is a turnover of cells within the tissue. This dynamic homeostasis is maintaned by numerous governing mechanisms which are finely tuned in such a way that the tissue remains in a homeostatic state, even across large timescales. Some of these governing mechanisms include cell motion, and cell fate selection through inter cellular signalling. However, it is not yet clear how to link these two processes, or how they may affect one another across the tissue. In this paper, we present a multicellular, multiscale model, which brings together the two phenomena of cell motility, and inter cellular signalling, to describe cell fate selection on a dynamic tissue. We find that the affinity for cellular signalling to occur greatly influences a cells ability to differentiate. We also find that our results support claims that cell differentiation is a finely tuned process within dynamic tissues at homeostasis, with excessive cell turnover rates leading to unhealthy (undifferentiated and unpatterned) tissues.

多细胞组织是许多生物系统和器官的基础。这些组织不是静态的，而是随时间动态变化的。即使总体结构保持不变，组织内的细胞也会发生更新。这种动态的动态平衡是由许多调节机制维持的，这些调节机制经过了微调，即使在较大的时间范围内，组织也可以保持稳态。这些控制机制中的一些机制包括细胞运动和通过细胞间信号传导进行的细胞命运选择。然而，目前尚不清楚如何将这两个过程联系起来，或者它们如何在整个组织中相互影响。在本文中，我们提出了一个多细胞，多尺度的模型，该模型将细胞运动和细胞间信号传递这两种现象结合在一起，描述动态组织中细胞命运的选择。我们发现，发生细胞信号传导的亲和力极大地影响细胞分化的能力。我们还发现，我们的研究结果支持声称细胞分化是动态平衡下动态组织内的微调过程，过度的细胞更新速率会导致不健康（未分化和无模式）的组织。