We investigated HLA class I (HLA-A, -B, and -C) and class II (HLA-DRB1, -DQB1, -DPA1, and -DPB1) alleles by NGS-based typing among 478 Brazilian individuals from two populations in the Barra Mansa city based on their self-declared skin color (Caucasian, N = 405, AFND-ID: 3729; Black, N = 73, AFND-ID: 3731) to calculate allelic and haplotypic frequencies, plus linkage disequilibrium. No locus deviated from Hardy-Weinberg equilibrium. Both populations shared the most frequent allele on HLA-A, -C, -DPA1, and -DPB1. Genotype and frequency data are available in the Allele Frequencies Net Database.

我们通过基于 NGS 的分型在来自两个群体的 478 名巴西个体中调查了 HLA I 类（HLA-A、-B 和 -C）和 II 类（HLA-DRB1、-DQB1、-DPA1 和 -DPB1）等位基因。 Barra Mansa 市根据他们自称的肤色（白种人，N = 405，AFND-ID：3729；黑色，N = 73，AFND-ID：3731）计算等位基因和单倍型频率，以及连锁不平衡。没有轨迹偏离 Hardy-Weinberg 平衡。两个种群在 HLA-A、-C、-DPA1 和 -DPB1 上共享最常见的等位基因。等位基因频率网络数据库中提供了基因型和频率数据。