Background and Objective: Recent advances in medical imaging like MRI, CT-Scan, Doppler ultrasound, etc. have made it possible to study the hemodynamics of cardiovascular system having different levels of vessel abnormalities.

Methods: Within this work, we have developed two different personalized lumped-parameter models of the human carotid arteries having elastic and viscoelastic vessel wall behaviors. The data used in developing the models of the carotid arteries is taken from a healthy subject and a patient having mild carotid stenosis $(55\%)$ near a bifurcation using doppler ultrasound. The data consists measurements of blood flow velocities and geometrical parameters at selected locations. Prior to the measurements, the key measurable geometrical parameters are identified by normalized local sensitivity analysis.

Results: Finally, both developed and personalized models of carotid arteries are validated against the blood flow measurements obtained near carotid bifurcation. We observe a good agreement between model simulations and blood flow measurements taken near the bifurcation i.e. $(r=0.94)$ for the healthy subject and $(r=0.96)$ for the patient having a stenosis near the bifurcation.

Conclusions: This work provides further evidence, that the hemodynamics near a bifurcation can be modelled well with a 0D approach, even with different levels of stenosis.

背景与目的： MRI，CT-Scan，多普勒超声等医学成像技术的最新发展使得研究具有不同程度血管异常的心血管系统的血液动力学成为可能。

方法：在这项工作中，我们已经开发了两种不同的具有弹性和粘弹性血管壁行为的人颈动脉个性化集总参数模型。用于开发颈动脉模型的数据取自健康受试者和患有轻度颈动脉狭窄的患者$（55％）$使用多普勒超声在分叉处附近。数据包括选定位置的血流速度和几何参数的测量值。在测量之前，可通过标准化的局部灵敏度分析确定关键的可测量几何参数。

结果：最后，针对颈动脉分叉附近获得的血流测量结果验证了发达的和个性化的颈动脉模型。我们观察到在分叉附近进行的模型模拟与血流测量之间的良好一致性，即$（\mathrm{[R}=0.94）$ 对于健康的对象和 $（\mathrm{[R}=0.96）$ 适用于分叉附近狭窄的患者。

结论：这项工作提供了进一步的证据，即使使用不同程度的狭窄，也可以使用0D方法很好地模拟分叉附近的血流动力学。