The metal-organic framework (MOF) UiO-66 is made of zirconium clusters coordinated with 1,4-benzenedicarboxylate linkers that is stable in water and is highly tolerant to extremely acidic or basic environments. Conversely, the zirconium clusters are affine to nucleophiles so the crystalline structures of UiO-66 can be converted into amorphous derivatives. In a mineral acid solution both protons and coordinating nucleophile are present. This study for the first time revealed that it is the strong nucleophile instead of proton deteriorate the crystalline structures of UiO-66. Also, the so-produced amorphous mesoporous matrix, if not totally dissolved, can be applied as an efficient adsorbent. The noted adsorption capabilities of Cu(II) and nucleophiles by these amorphous mesoporous matrix did not correlate with the structural crystallinity or the internal surface area; conversely, the doped nucleophiles were noted to contribute to the adsorption tendencies towards Cu(II) and phosphate species via electrostatic interactions and hydrogen bonding, respectively. Conversion of sacrificing UiO-66 template to amorphous matrix can be applied as an effective way to fabricate specific adsorbent with resistance to extreme pH and strong nucleophile challenges.

金属有机骨架（MOF）UiO-66由锆簇与1,4-苯二甲酸酯连接基配位而成，该连接基在水中稳定并且对极端酸性或碱性环境具有高度耐受性。相反，锆簇与亲核试剂有亲和力，因此UiO-66的晶体结构可以转化为无定形衍生物。在无机酸溶液中，质子和配位亲核试剂都存在。这项研究首次表明，它是强亲核试剂而不是质子破坏了UiO-66的晶体结构。同样，如果不能完全溶解，则可以将如此生产的非晶形介孔基质用作有效的吸附剂。这些无定形介孔基质对Cu（II）和亲核试剂的明显吸附能力与结构结晶度或内表面积无关。相反，人们注意到掺杂的亲核试剂分别通过静电相互作用和氢键促成对Cu（II）和磷酸盐物种的吸附趋势。可以将牺牲的UiO-66模板转化为无定形基质，作为制造具有抗极端pH和强亲核试剂挑战性的特定吸附剂的有效方法。