This work aimed to evaluate the optimum conditions for efficient extraction of phenolic acids, namely gallic acid (GA) and tannic acid (TA) from Aleppo oak by ultrasonic-probe assisted extraction (UPAE) method. Furthermore, an extensive study on kinetic, antioxidant activity and cost evaluation aspects in comparison with classical hydro-distillation extraction (CHDE) method was also examined. Sonication demonstrated a superior effect on the extraction of target compounds in which the UPAE method was seven times more efficient compared to the classical hydro-distillation extraction (CHDE) method. Result revealed that under optimized optimum condition of 40% duty cycle and 70 °C extraction temperature, GA and TA were yielded at 870.90 ± 0.03 mg GAE/g and 3157.97 ± 0.05 mg TAE/g, respectively. Kinetic analysis affirmed the extraction rate as controlling factor in extracting phenolic acids. Strong antioxidant activity was observed at a IC₅₀, 26.57 ± 0.03 μg/mL. Besides, the cost assessment study indicates that the extraction process requires US$ 0.25 and US$ 0.06 per mg/g extracts produced for CHDE and UPAE, respectively. Notably, findings revealed that UPAE method is four-fold more cost-effective compared to the CHDE method, providing a new direction for extracting active compounds from complex plants.

这项工作旨在评估通过超声探针辅助萃取（UPAE）方法从阿勒颇橡木中高效萃取酚酸（即没食子酸（GA）和单宁酸（TA））的最佳条件。此外，还对动力学，抗氧化活性和成本评估方面进行了广泛研究，与经典的水蒸馏萃取（CHDE）方法相比。超声处理显示出对目标化合物萃取的卓越效果，其中UPAE方法的效率是传统水蒸馏法（CHDE）的7倍。结果表明，在40％占空比和70°C提取温度的最佳最佳条件下，GA和TA的产率分别为870.90±0.03 mg GAE / g和3157.97±0.05 mg TAE / g。动力学分析确定了萃取率是萃取酚酸的控制因素。在室温下观察到强抗氧化剂活性。IC ₅₀，26.57±0.03微克/毫升。此外，成本评估研究表明，提取工艺需要每毫克/克CHDE和UPAE生产的提取物分别需要0.25美元和0.06美元。值得注意的是，研究结果表明，UPAE方法的成本效益是CHDE方法的四倍，为从复杂植物中提取活性化合物提供了新的方向。