Nano-hydroxyapatite (nano-Hap) and different Hap-based nanocomposites (NCs) containing nanocarbons with different morphologies (functionalized multiwall carbon nanotubes - fMWCNT, graphene oxide - GO, and fullerene - Ful), and gelatin (Gel) were studied to highlight the modification of their adsorption and desorption properties. The obtained Hap-based NCs were characterized using powder X-ray diffraction, laser diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. Moreover, ultraviolet-visible spectroscopy was used to investigate the adsorption and desorption properties of the obtained NCs. The adsorption experiments were performed with both ibuprofen (IBU, synthetic active substance) and anthocyanin (ANTO, natural active substance). The results revealed that the studied additives had little influence on improving the drug adsorption as compared to pure HAP. The adsorption energies were evaluated using density functional theory (DFT), which indicated that the interaction with GO is much stronger than the interaction with Ful, due to the formation of hydrogen bonds. The desorption experiments were carried out in simulated body fluid (SBF). fMWCNT and GO had a positive effect in the case of both natural and synthetic anti-inflammatory drugs, due to the morphology and the intermolecular interactions between the functional groups. The positive effect of Gel was observed in the adsorption studies of both substances, Gel increased the adsorption capacity of the NCs. The release profile of IBU was carried out using various mathematical models (zero-order, first-order, Higuchi, Hixon-Crowell, and Korsmeyer-Peppas).

研究了纳米羟基磷灰石（nano-Hap）和含有不同形态纳米碳的不同Hap基纳米复合材料（NCs）（功能化的多壁碳纳米管-fMWCNT，氧化石墨烯-GO和富勒烯-Ful）和明胶（Gel）以突出显示改变它们的吸附和解吸性能。使用粉末X射线衍射，激光衍射，透射电子显微镜和傅里叶变换红外光谱对获得的基于Hap的NC进行表征。此外，使用紫外可见光谱法研究了所得NCs的吸附和解吸性能。用布洛芬（IBU，合成活性物质）和花青素（ANTO，天然活性物质）进行吸附实验。结果表明，与纯HAP相比，所研究的添加剂对改善药物吸附的影响很小。使用密度泛函理论（DFT）评估了吸附能，表明由于形成氢键，与GO的相互作用比与Ful的相互作用强得多。解吸实验是在模拟体液（SBF）中进行的。由于功能基团之间的形态和分子间相互作用，fMWCNT和GO在天然和合成抗炎药中均具有积极作用。在两种物质的吸附研究中都观察到了凝胶的积极作用，凝胶增加了NCs的吸附能力。使用各种数学模型（零阶，一阶，Higuchi，