Cognitive dysfunction in idiopathic interstitial pneumonia (IIP) is an important clinical co-morbidity that is associated with impaired lung function. The aim of the work is to assess cognitive function in major IIP and to find out the relation between cognitive dysfunction and the oxygenation parameters. Fifty individuals were involved in the study; 30 patients with major IIP and 20 healthy individuals. Patients with IIP had significantly lower mini mental state examination (MMSE) score compared to the control group (P < 0.001). Wechsler Deterioration Index (WDI) revealed that 33.3% (n = 10) of the patients with IIP had sure cognitive impairment and 26.6% (n = 8) had ongoing cognitive deterioration. Patients with idiopathic pulmonary fibrosis (IPF) had lower cognitive function than other IIP. There is an impairment of cognitive function in patients with major IIP, particularly in IPF, as measured by WDI and MMSE. Further large studies are needed to assess the possible predictors of cognitive impairment and their effects on the patients’ outcome.

中文翻译：

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主要特发性间质性肺炎认知功能的研究

特发性间质性肺炎（IIP）的认知功能障碍是一种重要的临床合并症，与肺功能受损有关。该工作的目的是评估主要IIP的认知功能，并找出认知功能障碍与氧合参数之间的关系。五十个人参与了研究；30名主要IIP患者和20名健康个体。IIP患者的迷你精神状态检查（MMSE）得分明显低于对照组（P <0.001）。Wechsler恶化指数（WDI）显示，有33.3％（n = 10）的IIP患者具有肯定的认知障碍，有26.6％（n = 8）的患者持续进行认知能力下降。特发性肺纤维化（IPF）患者的认知功能低于其他IIP。根据WDI和MMSE的测量，重度IIP患者，特别是IPF患者的认知功能受损。需要进一步的大型研究来评估认知障碍的可能预测因素及其对患者预后的影响。