Plastic pollution is the accumulation of plastic objects in the Earth’s environment and is a global problem of increasing importance. The laboratory and health care industries contribute to this problem by the widely accepted single use of plastics, including microtiter plates used for compound testing. At AstraZeneca, we predict the use of more than 45,000 384-well and more than 11,000 1536-well microtiter plates per year. IonField Systems has developed a microplate cleaning system (MCS) powered by PlasmaKnife technology that uses cold plasma to clean microtiter plates. AstraZeneca proposed the use of this system for standard ANSI (https://slas.org/resources/information/industry-standards/) microtiter plate regeneration. Here we present the results of an evaluation using a model system involving the cleaning of plates following an enzyme-based biochemical assay, as well as the software and hardware enhancements that were incorporated into the production PlasmaKnife MCS. The method involved determining the level of inhibition achieved by residual compound following different cleaning protocols and showed that cleaning achieved in about 2 min was sufficient to remove trace compound contamination. Future work will focus on assessing the number of regeneration cycles that can be reliably achieved.

塑料污染是塑料物体在地球环境中的积累，是一个日益重要的全球性问题。实验室和医疗保健行业通过广泛接受塑料的单一用途导致了这个问题，包括用于化合物测试的微量滴定板。在阿斯利康，我们预测每年将使用超过 45,000 个 384 孔和超过 11,000 个 1536 孔微量滴定板。IonField Systems 开发了一种由 PlasmaKnife 技术驱动的微孔板清洁系统 (MCS)，该系统使用冷等离子体清洁微孔板。阿斯利康提议将该系统用于标准 ANSI (https://slas.org/resources/information/industry-standards/) 微量滴定板再生。在这里，我们展示了使用模型系统进行评估的结果，该模型系统涉及在基于酶的生化分析后清洁板，以及纳入生产 PlasmaKnife MCS 的软件和硬件增强功能。该方法涉及确定残留化合物按照不同的清洁方案实现的抑制水平，并表明在大约 2 分钟内实现的清洁足以去除痕量化合物污染。未来的工作将侧重于评估可以可靠实现的再生循环次数。该方法涉及确定残留化合物按照不同的清洁方案实现的抑制水平，并表明在大约 2 分钟内实现的清洁足以去除痕量化合物污染。未来的工作将侧重于评估可以可靠实现的再生循环次数。该方法涉及确定残留化合物按照不同的清洁方案实现的抑制水平，并表明在大约 2 分钟内实现的清洁足以去除痕量化合物污染。未来的工作将侧重于评估可以可靠实现的再生循环次数。