The subicular complex (hereafter referred as subiculum), which is reciprocally connected with the hippocampus and rhinal cortices, exerts a major control on hippocampal outputs. Over the last three decades, several studies have revealed that the subiculum plays a pivotal role in learning and memory but also in pathological conditions such as mesial temporal lobe epilepsy (MTLE). Indeed, subicular networks actively contribute to seizure generation and this structure is relatively spared from the cell loss encountered in this focal epileptic disorder. In this review, we will address: (i) the functional properties of subicular principal cells under normal and pathological conditions; (ii) the subiculum role in sustaining seizures in in vivo models of MTLE and in in vitro models of epileptiform synchronization; (iii) its presumptive role in human MTLE; and (iv) evidence underscoring the relationship between subiculum and antiepileptic drug effects. The studies reviewed here reinforce the view that the subiculum represents a limbic area with relevant, as yet unexplored, roles in focal epilepsy.

中文翻译：

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下突及其在局灶性癫痫病中的作用

与海马和鼻皮质相互连接的下突复合体（以下称为下突）主要控制海马输出。在过去的三十年中，几项研究表明，下突在学习和记忆中起着关键作用，而且在诸如内侧颞叶癫痫 (MTLE) 等病理状况中也起着关键作用。事实上，皮下网络积极促进癫痫发作，并且这种结构相对不受这种局灶性癫痫症中遇到的细胞损失的影响。在这篇综述中，我们将讨论：(i) 在正常和病理条件下的皮下主细胞的功能特性；(ii) 在 MTLE 体内模型和癫痫样同步体外模型中，下突在维持癫痫发作中的作用；(iii) 它在人类 MTLE 中的推定作用；(iv) 证据强调下丘脑和抗癫痫药物作用之间的关系。此处审查的研究强化了以下观点，即下叶代表边缘区域，在局灶性癫痫中具有相关但尚未探索的作用。