Solid organ transplant recipients (SOTRs) are susceptible to various cutaneous side effects as a consequence of long-term immunosuppressive therapy. Skin cancers and infections are well-studied complications that can cause death and/or allograft rejection. Other cutaneous drug reactions, such as inflammatory manifestations, have a high prevalence but are rarely studied. We analyzed these manifestations' prevalence and their association with immunosuppressants in transplant recipients from a Brazilian tertiary center. Among 532 SOTRs followed at our dermatology clinic, 60 (11.3%) developed some cutaneous adverse reactions to the immunosuppressants, with a median age at transplantation of 50.5 years and a median life span posttransplantation of seven years. Acneiform eruption was the most common drug reaction found (21 patients, 30.4%), followed by diffuse non-scarring alopecia (16 patients, 23.1%), lymphedema (10 patients, 14.5%), gingival hyperplasia (7 patients, 10.1%), hypertrichosis (6 patients, 8.7%) and sebaceous hyperplasia (9 patients, 13.1%). Adequate immunosuppression is an essential prerequisite for successful organ transplantation. In the immediate post-transplant period, significant immunosuppression is needed, but after that, the complications of excessive immunosuppression outweigh the risk of organ rejection. SORTs may present with a broad spectrum of inflammatory and cosmetic findings due to immunosuppressants that can impair life quality.

长期免疫抑制治疗的结果是，实体器官移植受者（SOTR）容易遭受各种皮肤副作用。皮肤癌和感染是经过充分研究的并发症，可能导致死亡和/或同种异体移植排斥。其他皮肤药物反应，例如炎症表现，患病率很高，但很少进行研究。我们分析了来自巴西第三中心的移植受者中这些表现的普遍性及其与免疫抑制剂的关联。在我们皮肤病学诊所接受的532种SOTR中，有60种（11.3％）对免疫抑制剂产生了一些皮肤不良反应，移植时的中位年龄为50.5岁，移植后的中位寿命为7年。痤疮爆发是最常见的药物反应（21例患者，占30.4％），其次是弥漫性非瘢痕性脱发（16例，23.1％），淋巴水肿（10例，14.5％），牙龈增生（7例，10.1％），肥大症（6例，8.7％）和皮脂腺增生（9例，1​​3.1） ％）。充分的免疫抑制是成功器官移植的必要前提。在移植后即刻，需要大量的免疫抑制，但是此后，过度的免疫抑制并发症会超过器官排斥的风险。由于免疫抑制剂会损害生活质量，因此SORT可能具有广泛的炎症和美容发现。充分的免疫抑制是成功器官移植的必要前提。在移植后即刻，需要大量的免疫抑制，但是此后，过度免疫抑制的并发症超过了器官排斥的风险。由于免疫抑制剂会损害生活质量，因此SORT可能具有广泛的炎症和美容发现。充分的免疫抑制是成功器官移植的必要前提。在移植后即刻，需要大量的免疫抑制，但是此后，过度免疫抑制的并发症超过了器官排斥的风险。由于免疫抑制剂会损害生活质量，因此SORT可能具有广泛的炎症和美容发现。