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Cicatrizing conjunctivitis as an uncommon manifestation of primary Sjögren's syndrome
The Ocular Surface ( IF 5.9 ) Pub Date : 2020-11-29 , DOI: 10.1016/j.jtos.2020.11.014
Yael Sharon 1 , David Cui 2 , Esen K Akpek 2 , David S Chu 3
Affiliation  

Purpose

To report occurrence of cicatrizing conjunctivitis as an extraglandular ocular manifestation of primary Sjögren's syndrome (SS).

Methods

Medical charts of all patients with SS evaluated at two tertiary ophthalmological referral centers were reviewed. Patients who demonstrated clinical findings of cicatrizing conjunctivitis were included in this review. Patient and disease-related data including ocular complications, therapies and outcomes were collected.

Results

Eight patients with a diagnosisis of SS were noted to have cicatrizing conjunctivitis findings over a period of 11 years (between 2009 and 2020). Mean age of patients was 79. All patients had a negative immunoreactant deposition in conjunctival biopsy. Mean follow-up time was 6 years (range, 18–197 months). Three patients had progression of conjunctival scarring. Worsening of vision occurred in 4 patients due to corneal complications, including ulceration, perforation and scarring.

Conclusions

SS is an under-recognized etiology of severe progressive cicatrizing conjunctivitis that can lead to ocular morbidity and loss of vision without appropriate management.



中文翻译:

结膜结膜炎是原发性干燥综合征的罕见表现

目的

报告瘢痕性结膜炎的发生是原发性干燥综合征(SS)的腺外眼部表现。

方法

回顾了在两个三级眼科转诊中心评估的所有SS患者的病历。证明瘢痕性结膜炎临床表现的患者包括在本评价中。收集患者和疾病相关的数据,包括眼部并发症,治疗方法和结果。

结果

八名诊断为SS的患者在11年内(2009年至2020年)发现结节性结膜炎。患者的平均年龄为79岁。所有患者的结膜活检中免疫反应沉积均为阴性。平均随访时间为6年(范围18-197个月)。3例患者结膜瘢痕进展。由于角膜并发症,包括溃疡,穿孔和瘢痕形成,使4名患者的视力恶化。

结论

SS是一种严重的进行性结ica性结膜炎的病因,人们对其认识不足,如果没有适当的治疗,可能会导致眼部疾病和视力丧失。

更新日期:2020-12-02
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