An enantioselective total synthesis of (R)-bgugaine and the first enantioselective total synthesis of (R)-irnidine are reported. The key steps are the asymmetric ‘clip-cycle’ formation of the pyrrolidine ring in 94:6 e.r., which is common to both natural products, followed by Liebeskind–Srogl coupling and Wolf-Kishner reduction. The route yields (R)-bgugaine and (R)-irnidine in 6 steps and in overall yields of 33% and 18% respectively.

中文翻译：

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（R）-双胍丁胺和（R）-乙啶的催化不对称全合成

的对映体选择性全合成（- [R）-bgugaine和（的第一对映选择性全合成- [R）-irnidine报告。关键步骤是在94：6 er中吡咯烷环的不对称“剪切循环”形成，这对两种天然产物都是常见的，随后是Liebeskind-Srogl偶联和Wolf-Kishner还原。该路线分6步产生（R）-古吉ine碱和（R）-亚氨酸idine，总产率分别为33％和18％。