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The role of vascular niche and endothelial cells in organogenesis and regeneration
Experimental Cell Research ( IF 3.3 ) Pub Date : 2020-11-30 , DOI: 10.1016/j.yexcr.2020.112398
Domenico Ribatti , Roberto Tamma , Tiziana Annese

The term vascular niche indicate the physical and biochemical microenvironment around blood vessel where endothelial cells, pericytes, and smooth muscle cells organize themselves to form blood vessels and release molecules involved in the recruitment of hematopoietic stem cells, endothelial progenitor cells and mesenchymal stem cells. The vascular niche creates a permissive environment that enables different cell types to realize their developmental or regenerative programs. In this context, the proximity between the endothelium and the new-forming cellular components of organs suggests an essential role of endothelial cells in the organs maturation. Dynamic interactions between specific organ endothelial cells and different cellular conponents are crucial for different organ morphogenesis and function. Conversely, organs provide cues shaping vascular network structure.



中文翻译:

血管生态位和内皮细胞在器官发生和再生中的作用

术语“血管生境”表示血管周围的物理和生化微环境,在该环境中内皮细胞,周细胞和平滑肌细胞自行组织形成血管,并释放参与造血干细胞,内皮祖细胞和间充质干细胞募集的分子。血管生态位创造了一个宽松的环境,使不同类型的细胞能够实现其发育或再生程序。在这种情况下,内皮与器官的新形成的细胞成分之间的接近性暗示了内皮细胞在器官成熟中的重要作用。特定器官内皮细胞与不同细胞成分之间的动态相互作用对于不同器官的形态和功能至关重要。反过来,

更新日期:2020-12-08
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