Abuse of antibiotics has led to the emergence of drug-resistant pathogens. Methicillin-resistant Staphylococcus aureus (MRSA) was reported just two years after the clinical use of methicillin, which can cause severe infections with high morbidity and mortality in both community and hospital. The treatment of MRSA infection is greatly challenging since it has developed the resistance to almost all types of antibiotics. As such, it is of great significance and importance to develop novel therapeutic approaches. The fast development of nanotechnology provides a promising solution to this dilemma. Functional nanomaterials and nanoparticles can act either as drug carriers or as antibacterial agents for antibacterial therapy. Herein, we aim to provide a comprehensive understanding of the drug resistance mechanisms of MRSA and discuss the potential applications of some functionalized nanomaterials in anti-MRSA therapy. Also, the concerns and possible solutions for the nanomaterials-based anti-MRSA therapy are discussed.

滥用抗生素导致了耐药病原体的出现。耐甲氧西林金黄色葡萄球菌（MRSA）在临床使用甲氧西林仅两年后就被报道，甲氧西林会导致严重的感染，在社区和医院中都具有很高的发病率和死亡率。由于MRSA对几乎所有类型的抗生素都有抗药性，因此治疗MRSA感染具有极大的挑战性。因此，开发新颖的治疗方法具有重要的意义和重要性。纳米技术的快速发展为解决这一难题提供了有希望的解决方案。功能性纳米材料和纳米颗粒可以充当药物载体或用作抗菌治疗的抗菌剂。在此，我们旨在提供对MRSA耐药机制的全面理解，并讨论某些功能化纳米材料在抗MRSA治疗中的潜在应用。也，