Immune checkpoint blocking (ICB) antibodies have shown great success in the clinic, but their low response rate in patients with immunosuppressive cold tumors remains a huge challenge. Inspired by the capability of immunogenic cell death (ICD) to convert tumors from cold to hot, we developed a corn-like Au/Ag nanorod (NR) that can induce the ICD of tumor cells under 1064-nm light irradiation. The corn-like Au/Ag NRs plus NIR-II light irradiation strikingly increased the tumor infiltration of T cells and provoked a systemic immune response to reprogram the immunosuppressive cold tumor microenvironment; these NRs synergized with ICB antibodies to efficiently inhibit distant tumor growth. Encouragingly, the combination of aCTLA4 and Au/Ag NRs plus 1064-nm light irradiation elicited a strong immunological memory effect that protected against tumor recurrence.

免疫检查点阻断（ICB）抗体在临床上已显示出巨大的成功，但是对于免疫抑制性冷肿瘤患者，其低应答率仍然是一个巨大的挑战。受免疫原性细胞死亡（ICD）将肿瘤从冷转变为热的能力的启发，我们开发了一种玉米样Au / Ag纳米棒（NR），它可以在1064 nm光照射下诱导肿瘤细胞的ICD。玉米样Au / Ag NRs加上NIR-II光照射显着增加了T细胞的肿瘤浸润，并引发了系统性免疫反应，以重新编程免疫抑制性冷肿瘤微环境。这些NR与ICB抗体协同作用，可有效抑制远处的肿瘤生长。令人鼓舞的