It has been established that scar acellular matrices (AMs), which allow cell proliferation, have similar characteristics. The aim of this study was to investigate the repair effect of scar AMs on animals, thus providing a reference for clinical application. Selected mature and immature scar AMs were implanted into animals, and then a negative control group was set for comparison. The effect of scar AMs on wound healing was observed through tissue staining, RT-qPCR, and immunohistochemistry. The materials showed milder inflammation and faster extracellular matrix (ECM) deposition than the negative control group. The ECM deposition and new vessels increased over time. However, the arrangement of ECM in mature scar AM was more regular than in immature scar AM and the negative control group, and more new vessels grew in the mature scar AM group than in the immature scar AM group and negative control group over the same period. The transforming growth factor-β level was elevated at one month, two months, and six months. COLA1 and vimentin levels all peaked at six months. Matrix metalloproteinase and TIMP1 were also elevated at different months. Collectively, scar AMs can effectively promote wound healing and vascularization. Mature scar AMs have a better regeneration effect.

已经确定允许细胞增殖的瘢痕无细胞基质 (AM) 具有相似的特征。本研究旨在探讨瘢痕AMs对动物的修复作用，为临床应用提供参考。将选定的成熟和未成熟瘢痕AMs植入动物体内，然后设置阴性对照组进行比较。通过组织染色、RT-qPCR 和免疫组织化学观察瘢痕 AMs 对伤口愈合的影响。与阴性对照组相比，这些材料显示出更轻微的炎症和更快的细胞外基质 (ECM) 沉积。ECM 沉积和新血管随着时间的推移而增加。然而，成熟瘢痕AM中ECM的排列比未成熟瘢痕AM和阴性对照组更规则，同期成熟瘢痕AM组新生血管较未成熟瘢痕AM组和阴性对照组多。1个月、2个月和6个月转化生长因子-β水平升高。COLA1 和波形蛋白水平都在六个月达到峰值。基质金属蛋白酶和 TIMP1 在不同月份也升高。总的来说，瘢痕 AMs 可以有效促进伤口愈合和血管形成。成熟的疤痕AMs具有更好的再生效果。瘢痕AMs可以有效促进伤口愈合和血管化。成熟的疤痕AMs具有更好的再生效果。瘢痕AMs可以有效促进伤口愈合和血管化。成熟的疤痕AMs具有更好的再生效果。