Association of ABCB1 and CYP450 Gene Polymorphisms and their DNA Methylation Status with Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Population,Genetic Testing and Molecular Biomarkers

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Association of ABCB1 and CYP450 Gene Polymorphisms and their DNA Methylation Status with Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Population
Genetic Testing and Molecular Biomarkers ( IF 1.1 ) Pub Date : 2020-12-16 , DOI: 10.1089/gtmb.2020.0201
Ronglan Huang ₁ , Qinghao Zhan ₁ , Wenbin Hu _{1,

2} , Renmin Yang _{1,

2} , Nan Cheng _{1,

2} , Yongsheng Han _{1,

2} , Xiuyu Yue ₂

Affiliation

Objective: Osteonecrosis of the femoral head (ONFH) is a severe pathological state with multiple etiologies. Steroid hormone metabolism-related genes play an important role in ONFH. The aim of this study was to investigate the relationships between polymorphisms of the drug-metabolizing enzyme gene, cytochrome P450 (CYP450), and the drug transporter gene, ATP-binding cassette subfamily B member 1 (ABCB1), as well as their DNA methylation status with the pathogenesis of steroid-induced ONFH.

更新日期：2020-12-22

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