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Bi3+-Doped BaYF5:Yb,Er Upconversion Nanoparticles with Enhanced Luminescence and Application Case for X-ray Computed Tomography Imaging
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-11-30 , DOI: 10.1021/acs.inorgchem.0c01818 Ran Luo 1 , Lei Chen 2 , Qinyu Li 1 , Jie Zhou 2 , Linqiang Mei 2 , Zhanglei Ning 1 , Yan Zhao 1 , Mengjiao Liu 1 , Xin Lai 1 , Jian Bi 1 , Wenyan Yin 2, 3 , Daojiang Gao 1
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-11-30 , DOI: 10.1021/acs.inorgchem.0c01818 Ran Luo 1 , Lei Chen 2 , Qinyu Li 1 , Jie Zhou 2 , Linqiang Mei 2 , Zhanglei Ning 1 , Yan Zhao 1 , Mengjiao Liu 1 , Xin Lai 1 , Jian Bi 1 , Wenyan Yin 2, 3 , Daojiang Gao 1
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In this work, BaYF5:20%Yb3+/2%Er3+/x%Bi3+ (abbreviated as BaYF5:Yb,Er,Bix, where x = 0–3.0) upconversion nanoparticles (UCNPs) with various doping concentrations of Bi3+ were synthesized through a simple hydrothermal method. The influence of the doping amount of Bi3+ on the microstructures and upconversion luminescence (UCL) properties of the BaYF5:Yb,Er,Bix UCNPs was studied in detail. The doping concentration of Bi3+ has little influence on the microstructures of the UCNPs but significantly impacts their UCL intensities. Under excitation of a 980 nm near-IR laser, the observed UCL intensities for the BaYF5:Yb,Er,Bix UCNPs display first an increasing trend and then a decreasing trend with an increase in the ratio x, giving a maximum at x = 2.5. A possible energy-transfer process and simplified energy levels of the BaYF5:Yb,Er,Bix UCNPs were proposed. The potential of the BaYF5:Yb,Er,Bix UCNPs as contrast agents for computerized tomography (CT) imaging was successfully demonstrated. An obvious accumulation of BaYF5:Yb,Er,Bix in tumor sites was achieved because of high passive targeting by the enhanced permeability and retention effect and relatively low uptake by a reticuloendothelial system such as liver and spleen. This work paves a new route for the design of luminescence-enhanced UNCPs as promising bioimaging agents for cancer theranostics.
中文翻译：
Bi 3+掺杂的BaYF 5：Yb，Er上转换纳米粒子具有增强的发光性能及X射线计算机断层扫描成像的应用案例
在这项工作中，BaYF 5：20％Yb 3+ / 2％Er 3+ / x％Bi 3+（缩写为BaYF 5：Yb，Er，Bi x，其中x = 0–3.0）具有通过简单的水热法合成了各种掺杂浓度的Bi 3+。详细研究了Bi 3+的掺杂量对BaYF 5：Yb，Er，Bi x UCNPs的微观结构和上转换发光（UCL）性能的影响。Bi 3+的掺杂浓度对UCNP的微结构影响很小，但会显着影响其UCL强度。在980 nm近红外激光激发下，观察到的BaYF 5：Yb，Er，Bi x UCNPs的UCL强度首先呈现出上升趋势，然后随着比率x的增加而呈下降趋势，从而在x处达到最大值= 2.5。提出了BaYF 5：Yb，Er，Bi x UCNPs的可能的能量转移过程和简化的能级。成功地证明了BaYF 5：Yb，Er，Bi x UCNPs作为计算机断层扫描（CT）成像的造影剂的潜力。BaYF 5的明显积累：Yb，Er，Bi x在肿瘤部位得以实现是因为通过增强的通透性和保留作用以及通过网状内皮系统（如肝和脾）的相对较低的摄取而实现了高被动靶向。这项工作为设计增强发光的UNCP作为癌症治疗学的有前途的生物成像剂，开辟了一条新途径。
更新日期：2020-12-21
中文翻译：
Bi 3+掺杂的BaYF 5：Yb，Er上转换纳米粒子具有增强的发光性能及X射线计算机断层扫描成像的应用案例
在这项工作中，BaYF 5：20％Yb 3+ / 2％Er 3+ / x％Bi 3+（缩写为BaYF 5：Yb，Er，Bi x，其中x = 0–3.0）具有通过简单的水热法合成了各种掺杂浓度的Bi 3+。详细研究了Bi 3+的掺杂量对BaYF 5：Yb，Er，Bi x UCNPs的微观结构和上转换发光（UCL）性能的影响。Bi 3+的掺杂浓度对UCNP的微结构影响很小，但会显着影响其UCL强度。在980 nm近红外激光激发下，观察到的BaYF 5：Yb，Er，Bi x UCNPs的UCL强度首先呈现出上升趋势，然后随着比率x的增加而呈下降趋势，从而在x处达到最大值= 2.5。提出了BaYF 5：Yb，Er，Bi x UCNPs的可能的能量转移过程和简化的能级。成功地证明了BaYF 5：Yb，Er，Bi x UCNPs作为计算机断层扫描（CT）成像的造影剂的潜力。BaYF 5的明显积累：Yb，Er，Bi x在肿瘤部位得以实现是因为通过增强的通透性和保留作用以及通过网状内皮系统（如肝和脾）的相对较低的摄取而实现了高被动靶向。这项工作为设计增强发光的UNCP作为癌症治疗学的有前途的生物成像剂，开辟了一条新途径。
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