The globally inimitable and unremitting outbreak of COVID-19 infection confirmed the emergency need for critical detection of human coronavirus infections. Laboratory diagnostic tests and imaging modalities are two test groups used for the detection of COVID-19. Nowadays, real-time polymerase chain reaction (RT-PCR) and computed tomography (CT) have been frequently utilized in the clinic. Some limitations that confront with these tests are false-negative results, tests redone for follow-up procedure, high cost, and unable to do for all patients. To overcome these limitations, modified and alternative tests must be considered. Among these tests, RdRp/Hel RT-PCR assay had the lowest diagnostic limitation and highest sensitivity and specificity for the detection of SARS-CoV-2 RNA in both respiratory tract and nonrespiratory tract clinical specimens. On the other hand, lung ultrasound (LUS) and magnetic resonance imaging (MRI) are CT-alternative imaging modalities for the management, screening, and follow-up of COVID-19 patients.

中文翻译：

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对快速准确诊断 COVID-19 的实验室测试和成像方式的新见解：常规 RT-PCR 和 CT 的替代建议 — 文献综述


全球范围内独一无二且持续不断的 COVID-19 感染爆发证实了对人类冠状病毒感染进行严格检测的紧急需求。实验室诊断测试和成像方式是用于检测 COVID-19 的两个测试组。目前，实时聚合酶链反应（RT-PCR）和计算机断层扫描（CT）已在临床上得到广泛应用。这些测试面临的一些限制是假阴性结果、为后续程序重新进行测试、成本高以及无法对所有患者进行测试。为了克服这些限制，必须考虑修改和替代测试。在这些测试中，RdRp/Hel RT-PCR 检测对于呼吸道和非呼吸道临床标本中 SARS-CoV-2 RNA 的检测具有最低的诊断局限性和最高的敏感性和特异性。另一方面，肺部超声 (LUS) 和磁共振成像 (MRI) 是用于管理、筛查和随访 COVID-19 患者的 CT 替代成像方式。