Detection and quantification of chiral enantiomers of biomolecules are of considerable importance for biomedical diagnostics and pathogen analyses. However, the chiral signals from natural molecules are typically small and weak; a long measuring time and a large amount of samples are needed to fulfill the detection limit for the present technique. How to improve the detection efficiency for realizing ultrasensitive probing of chiral molecules has become a key problem. Here we propose a scheme to perform ultrasensitive detection of chiral molecules based on degeneracy states of orthogonal polarization modes in the achiral dielectric nanostructure. The degeneracy states are realized by designing dielectric photonic crystal slabs with air holes. Based on such degeneracy states, homogeneous superchiral fields of both handednesses over arbitrarily large areas can be obtained in a wide spectral range, resulting in the enhancement of the circular dichroism signal by more than three orders of magnitude, thus paving the road toward ultrasensitive characterization and quantification of molecular chirality.

中文翻译：

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基于具有气孔的介电光子晶体平板，强大的超手性场和生物分子的超灵敏手性传感器

生物分子的手性对映异构体的检测和定量对于生物医学诊断和病原体分析非常重要。然而，来自天然分子的手性信号通常很小且微弱。为了满足本技术的检测极限，需要很长的测量时间和大量的样品。如何提高检测效率以实现手性分子的超灵敏探测已成为关键问题。在这里，我们提出了一种基于非手性介电纳米结构中正交极化模式的简并状态来执行手性分子超灵敏检测的方案。退化状态是通过设计带有气孔的介电光子晶体平板来实现的。基于这种退化状态，