Killer cell immunoglobulin-like receptors (KIR) consists of activating and inhibitory genes are essential for natural killer cell education. To determine the association of KIRs with susceptibility to invasive Breast cancer (BC), genotyping of 16 KIRs was performed by sequence-specific primers-polymerase chain reaction in 226 confirmed cases of BC with defined estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) status and 226 healthy controls (CNs). We observed a lower frequency of 2DL1 and 2DS4del along with increased frequency of 2DS4fl in cases compared to CNs. Further analysis revealed a higher frequency of KIR2DL2, 2DS1, 2DS2,3DS1 in ER+ cases, 2DL2, 2DL5 in PR+ and 2DL1 in HER2+ cases compared to CNs. The detrimental role of KIR2DS4fl was observed in ER+ and PR+ cases whereas 2DS4del confers protection against ER+, PR+, and HER2+ cases. We noted the predisposing role of Bx genotype, KIR2DS1, 2DS2, 2DS5, 2DL2, 2DL5 for lymphatic invasion in ER+ cases along with a higher rate of lymph node metastasis (LNM) in carriers of Bx genotype and KIR2DS1 in ER+ cases. We suggest a link between B haplotype associated genes with the increased risk of lymphatic invasion and LNM, particularly in ER+ cases of BC.

杀伤细胞免疫球蛋白样受体（KIR）由激活的和抑制的基因是天然杀伤细胞教育必不可少的。要确定的关联KIR s的易感性的浸润性乳腺癌（BC），16的基因分型KIR通过序列特异性引物聚合酶链反应在BC的具有确定雌激素受体（ER），孕酮受体226证实的病例执行S（ PR）和人表皮生长因子2（HER2）状态和226个健康对照（CNS）。我们观察到的较低频率，2DL1和2DS4del增加的频率一起2DS4fl相比的CN的情况下。进一步的分析显示的更高的频率KIR2DL2，2DS1，2DS2,3DS1在ER +的情况下，2DL2，2DL5在PR +和2DL1在HER2 +的情况相比的CN。在ER +和PR +病例，而2DS4del赋予抗ER +，PR +和HER2 +的情况下保护观察KIR2DS4fl的有害作用。我们注意到Bx的基因型的诱发作用KIR2DS1，2DS2，2DS5，2DL2，2DL5为Bx的基因型和携带者在ER +病例淋巴结转移率较高淋巴结转移（LNM）沿KIR2DS1在ER +案例。我们建议用淋巴管浸润和淋巴结转移的风险增加特别是在ER + BC的情况说明B单倍型相关的基因之间的联系。