Abstract

A growing body of evidence over the past two decades suggests that well-designed biomaterials can stimulate the homing of resident stem cells to damaged locations, and orchestrate their activities and functions to facilitate tissue regeneration. To achieve clinical transition and commercial success, regenerative biomaterials scaffold are needed not only to be effective and secure but also cost-effective and convenient for use and distribution. The current review aims to discuss various stem cells and biomaterials with their regenerative potential in different organs. Next, we highlight the current challenges for designing biomaterials and discuss the future directions for biomaterials in regenerative therapies.

摘要

在过去的二十年中，越来越多的证据表明，精心设计的生物材料可以刺激常驻干细胞归巢到受损部位，并协调它们的活动和功能以促进组织再生。为了实现临床转化和商业成功，再生生物材料支架不仅需要有效和安全，而且具有成本效益和便于使用和分发的特点。本综述旨在讨论各种干细胞和生物材料及其在不同器官中的再生潜力。接下来，我们将重点介绍当前设计生物材料的挑战，并讨论生物材料在再生疗法中的未来方向。