Abstract

Oleuropein has several beneficial properties. Strong evidences of its role in preventing osteoarthritis and playing analgesic and sedative effects are gaining. Starting from that, we entrapped a vegetal bioactive matrix rich in oleuropein into calcium ions crosslinked gellan gum and hyaluronan formulations. Infrared spectroscopy and thermal analysis confirmed the absence of significant interactions between the polysaccharide shells and the bioactive matrix, thus guaranteeing a burst release of oleuropein. The adequate mechanical performance of the systems for the foreseen application as viscosupplement was also verified. Cytocompatibility of developed systems toward fibroblasts and human chondrocytes was assessed.

摘要

橄榄苦苷有几个有益的特性。强有力的证据表明其在预防骨关节炎和发挥镇痛和镇静作用方面的作用正在获得。从那开始，我们将富含橄榄苦苷的植物生物活性基质嵌入到钙离子交联结冷胶和透明质酸配方中。红外光谱和热分析证实多糖壳和生物活性基质之间不存在显着的相互作用，从而保证了橄榄苦苷的突然释放。还验证了该系统对于作为粘性补充剂的预期应用的足够机械性能。评估了已开发系统对成纤维细胞和人类软骨细胞的细胞相容性。