Abstract

Porous microspheres have interconnecting external and internal pore structure resulting in enormous specific surface area and have drawn attention for drug delivery. In this work, poly(l-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) porous microspheres were prepared by a combined solvent evaporation and particle leaching method using gelatin as a porogen. The effects of preparation parameters on the morphologies of the porous microspheres were studied. The resultant microspheres showed porous surfaces and a three-dimensional internal network structure with interconnecting pores. The porous microsphere size decreased with increasing stirring speed and decreasing PLLGC concentration. There were fewer micropores on the surfaces of the microspheres with increasing temperature. The number of the pores and pore size on the surface of the microspheres increased with increasing gelatin content. By appropriate control of these factors (stirring speed 300 rpm, PLLGC solution concentration 1.0 wt%, temperature 0 °C, and gelatin concentration 7.5 wt%), a suitable porous microsphere, with a mean diameter of 200 μm, was prepared as a potential drug delivery agent.

摘要

多孔微球具有相互连接的外部和内部孔结构，从而导致巨大的比表面积，并引起了药物输送的注意。在这项工作中，poly（l通过使用明胶作为致孔剂的溶剂蒸发和颗粒浸出相结合的方法，制备了β-丙交酯-乙交酯-乙交酯-ε-己内酯）（PLLGC）多孔微球。研究了制备参数对多孔微球形态的影响。所得的微球显示出多孔表面和具有互连孔的三维内部网络结构。多孔微球尺寸随着搅拌速度的增加和PLLGC浓度的降低而减小。随着温度升高，微球表面上的微孔减少。随着明胶含量的增加，微球表面的孔数和孔径增加。通过适当控制这些因素（搅拌速度为300 rpm，PLLGC溶液浓度为1.0 wt％，温度为0°C，