The aim of this study is to examine the effect of cordyceps acid (CA) on lung cancer in mice. A lung cancer animal model was established by inoculating lung cancer cells under the armpit of nude mice. The mental state, body weight, and tumor growth of nude mice were recorded in detail. The levels of Nrf‐2/HO‐1/NLRP3/NF‐κB pathway and apoptosis in tumor tissues of nude mice were detected by the Western blot analysis and immunohistochemical methods. Our results show that CA inhibited lung cancer by regulating the Nrf‐2/HO‐1/NLRP3/NF‐κB signal. In summary, CA has an obvious tumor inhibiting effect on lung cancer via regulation of the Nrf‐2/HO‐1/NLRP3/NF‐κB signal.

中文翻译：

---

冬虫夏草酸可减轻裸鼠的肺癌

这项研究的目的是检查虫草酸（CA）对小鼠肺癌的影响。通过在裸鼠腋下接种肺癌细胞来建立肺癌动物模型。详细记录裸鼠的精神状态，体重和肿瘤生长。通过蛋白质印迹分析和免疫组织化学方法检测裸鼠肿瘤组织中Nrf / 2 / HO-1 / NLRP3 /NF-κB通路的水平和细胞凋亡。我们的结果表明，CA通过调节Nrf-2 / HO-1 / NLRP3 /NF-κB信号抑制肺癌。总之，CA通过调节Nrf-2 / HO-1 / NLRP3 /NF-κB信号对肺癌具有明显的肿瘤抑制作用。