Lymphatic filariasis (LF) is the second leading cause of parasitic disabilities that affects millions of people in India and several other tropical countries. The complexity of this disease is endorsed by various immunopathological consequences such as lymphangitis, lymphadenitis and elephantiasis. The immune evasion strategies that a filarial parasite usually follows are chiefly initiated with the communication between the invaded parasites and parasite‐derived molecules, with the Toll‐like receptors (TLRs) present on the surface of the antigen‐presenting cells (APCs). Classically, the filarial parasites interact with the DCs resulting in lowering of CD4⁺ T‐cell responses. These CD4⁺ T‐cell responses are the key players behind the immune‐mediated pathologies associated with LF. In chronic stage, the canonical pro‐inflammatory immune responses are shifted towards an anti‐inflammatory subtype, which is favouring the parasite survivability within the host. The central theme of this review article is to present the overall immune response elicited when an APC, particularly a DC, encounters a filarial parasite.

中文翻译：

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树突状细胞，丝虫和寄生虫分子之间的相互作用在调节宿主免疫反应中的综述

淋巴丝虫病（LF）是导致印度和其他几个热带国家数百万人感染寄生虫的第二个主要原因。该疾病的复杂性受到各种免疫病理后果的认可，例如淋巴管炎，淋巴结炎和象皮病。丝虫通常遵循的免疫逃避策略主要是通过被入侵的寄生虫与寄生虫衍生的分子之间的交流而启动的，抗原呈递细胞（APC）的表面存在Toll样受体（TLR）。传统上，丝虫寄生虫与DC相互作用，导致CD4 ⁺ T细胞反应降低。这些CD4 ⁺T细胞反应是与LF相关的免疫介导的病理学背后的关键因素。在慢性阶段，规范的促炎免疫反应向抗炎亚型转移，这有利于宿主体内的寄生虫存活。这篇综述文章的中心主题是介绍当APC（尤其是DC）遇到丝虫寄生虫时引发的总体免疫反应。