Recent Developments in the Synthetic Strategies of 4‐Quinolones and Its Derivatives,ChemistrySelect

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Recent Developments in the Synthetic Strategies of 4‐Quinolones and Its Derivatives
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-11-30 , DOI: 10.1002/slct.202003570
Gurpreet Singh ₁ , Varsha Devi ₁ , Vikramdeep Monga ₁

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The ubiquitous presence of 4‐quinolones and its derivatives in a wide range of natural as well as synthetic drug molecules made them molecule of utmost importance for organic and medicinal chemists. Their wide array of biological activities such as antimicrobial, anticancer, anti‐HIV, genitourinary infection, antifilarial, etc., has augmented their appeal both for synthetic and medicinal chemistry campaigns. Moreover, they are valuable intermediates for the synthesis of various fused heterocyclic compounds of synthetic and medicinal importance. Considering their array of synthetic and biological importance, new strategies for the synthesis of 4‐quinolones and their derivatives have been designed and successfully demonstrated by researchers around the globe. The present review covers recent advances in the synthetic chemistry of 4‐quinolones since 2015 along with an insight into their mechanistic studies. We hope that the review article will serve as a valuable tool for the scientific community engaged in the synthesis and utilization of 4‐quinolones and their derivatives.

中文翻译：

4-喹诺酮类及其衍生物合成策略的最新进展

在广泛的天然和合成药物分子中普遍存在4-喹诺酮及其衍生物，这使它们成为有机化学和药用化学家最重要的分子。它们广泛的生物学活性，例如抗微生物，抗癌，抗艾滋病毒，泌尿生殖道感染，抗丝虫病等，增强了它们对合成化学和药物化学运动的吸引力。而且，它们是用于合成具有合成和医学重要性的各种稠合杂环化合物的有价值的中间体。考虑到它们在合成和生物学上的重要性，已经设计出了合成4-喹诺酮及其衍生物的新策略，并已被全球研究人员成功证明。本综述涵盖自2015年以来4-喹诺酮类化合物合成化学的最新进展以及对它们的机理研究的见解。我们希望这篇评论文章对从事4-喹诺酮及其衍生物的合成和利用的科学界来说，将是一个有价值的工具。

更新日期：2020-12-01

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